Table 4. Results of protein-protein link evaluation in DAPPLE. List of indirect interactors.

Protein	number of binding proteins	Binding proteins	crude p-value	corrected p-value	Function
CDH1	2	CTNND2, BOC	0.001	0.008	Calcium-dependent cell-adhesion protein
CDH2	2	CTNND2, BOC	0.001	0.008	Calcium-dependent cell-adhesion protein
IL6	2	PRLR, ZBTB16	0.001	0.008	Cytokine functioning in inflammation and the maturation of B cell
EIF2S2	2	EIF3H, ZBTB16	0.005	0.039	Eukaryotic translation initiation factor 2
CTNNB1	3	CTNND2, BOC, CSNK1A1L	0.005	0.039	Adherens junction protein, adhesion between cells

Presented p-values reflect the probability that by chance individual interactors would be as connected to seed proteins (S2 Table) as was observed in the constructed network.