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. 2015 Apr 13;10(4):e0122678. doi: 10.1371/journal.pone.0122678

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© 2015 Yu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — Expression of PAR4 and TFF2 was measured in 38 colorectal cancer patients by real-time PCR. (A) PAR4 mRNA was increased in 86% (12 of 14) lymph node invasive tumors and 42% (10 of 24) non-invasive tumors. TFF2 mRNA was increased in 93% (13 of 14) lymph node invasive tumors and 38% (9 of 24) non-invasive tumors. There was significant difference of PAR4 (p = 0.008) and TFF2 (p = 0.001) mRNA expression between lymph node invasive tumors and non-invasive tumors; (B) PAR4 mRNA was increased in 88% (14 of 16) poor-differentiated cancers and 36% (8 of 22) well-/moderated-differentiated cancers. TFF2 mRNA was increased in 81% (13 of 16) poor-differentiated cancers and 46% (9 of 22) well-/moderated-differentiated cancers. Also, there is a significant difference of PAR4 (p = 0.001) and TFF2 (p = 0.002) mRNA expression between poor-differentiated and well-/moderated-differentiated cancers; Mean fold increase in the tumor tissue in relative to non-neoplastic colorectal tissue was shown. Median (quartile 25, quartile 75) was used to compare folds of PAR4 (TFF2) increase in lymph node invasive tumors and non-invasive tumors, and poor-differentiated cancers and well-/moderated-differentiated cancers. The increased folds of “>1” were defined as “increased”, whereas increased folds of “≤1” were defined as “not increased”.