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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2014 Jun 9;73:411–420. doi: 10.1016/j.freeradbiomed.2014.06.002

Figure 4. 4-HNE and 4-ONE adduction of GRP78 results in a concentration-dependent decrease in ATP hydrolysis.

Figure 4

Treatment of GRP78 with 4-HNE (open bars) or 4-ONE (closed bars) reveals a corresponding decrease in ATPase activity. Estimated IC50 values were calculated revealing a Ki of 51.8μM for 4-HNE and a Ki of 43.9μM for 4-ONE.