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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2014 Jun 9;73:411–420. doi: 10.1016/j.freeradbiomed.2014.06.002

Figure 5. Chaperone-mediated refolding of CS and MDH is preserved following adduction.

Figure 5

GRP78-mediated refolding of (A) MDH or (B) CS is unaffected by electrophile adduction with either 4-HNE (closed bars) or 4-ONE (open bars). (C) Sequence alignment using ClustalW demonstrates a conserved Cys residue in electrophile-susceptible HSPs. HSPs lacking this Cys residue are presented in green font. Mean is plotted with error bars representing SEM.