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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Biol Psychiatry. 2014 Feb 22;76(6):438–446. doi: 10.1016/j.biopsych.2014.02.010

Figure 1. Schematic of streams of analysis.

Figure 1

As part of the intramural NIMH study of typical development and childhood-onset schizophrenia (COS), 525 high-resolution magnetic resonance imaging scans were acquired on 208 subjects, 102 with COS. For each scan, thickness was estimated at ~80,000 cortical vertices via MNI’s CIVET pipeline, and penalized splines were used to estimate maturational trajectories (thickness as a function of age). Using only healthy subjects, developmental modules were derived by clustering vertices with similarly shaped maturational trajectories. Using both healthy subjects and subjects with COS, schizophrenia-related alterations in cortical maturation were tested for all cortical vertices. Finally, it was determined whether schizophrenia-related alterations in maturational trajectories were influenced by the organization of normative developmental modules.