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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Clin Gastroenterol Hepatol. 2014 Oct 13;13(5):1000–1008.e3. doi: 10.1016/j.cgh.2014.10.008

Figure 1. Hyperinsulinemia and dyslipidemia in NAFLD.

Figure 1

Figure 1

Figure 1

Figure 1

A. Compared to controls, patients with NAFLD and NASH had higher hepatic sterol regulatory element binding protein-1 (SREBP-1) expression (P<.03 NAFLD/NASH vs control). Laminin was used as a loading control.

B. Rate of 3H-acetate and 14C-palmitate incorporation into triglycerides by hepatocytes was increased in NAFLD/NASH (P<.01) and decreased with progression to cirrhosis (P<.01 NAFLD/NASH vs cirrhosis).

C. Rate of 3H-acetate into cholesterol in hepatocytes was significantly higher in NAFLD/NASH (P<.05 vs controls) and trended down with progression to cirrhosis (p=0.07 NAFLD/NASH vs cirrhosis).

D. Desmosterol:total cholesterol ratio was significantly higher in subjects with NAFLD and NASH compared to lean and obese controls (P<.02 lean/obese controls vs. NAFLD/NASH). All data is presented as means ± S.E.M.