Table 1.
Clinical and Histological Characteristics of Study Participants.
| Lean Normal (N=81) |
Obese Normal (N=81) |
NAFLD (N=81) |
|
|---|---|---|---|
| DEMOGRAPHICS | |||
| Age (years) | 57±11 | 54±13 | 54±13 |
| BMI (kg/m2) | 22.3±1.7 | 32.5±6.1 | 32.9±6.0* |
| Gender (%Male) | 71% | 71% | 62% |
| ETHNICITIES (% of cohort) | |||
| Caucasian | -- | -- | 94.6 |
| African American | -- | -- | 2.7 |
| Other | -- | -- | 2.7 |
| AMINOTRANSFERAES | |||
| ALT (IU/mL) | 17±5 | 17±5 | 56±39** |
| AST (IU/mL) | 22±6 | 20±4 | 45±31** |
| HISTOLOGY | |||
| Steatosis (%) | |||
| Less than 5% | -- | -- | 2.5 |
| Between 5–33% | -- | -- | 48.8 |
| Between 34–66% | -- | -- | 35.9 |
| More than 66% | -- | -- | 14.1 |
| Lobular Inflammation (%) | |||
| None | -- | -- | 11.7 |
| Less than 2/20× HPF | -- | -- | 63.6 |
| Between 2–4/20× per HPF | -- | -- | 22.1 |
| More than 4/20× per HPF | -- | -- | 2.6 |
| Cytologic Ballooning (%) | |||
| None | -- | -- | 46.2 |
| Few | -- | -- | 34.6 |
| Many | -- | -- | 19.2 |
| Fibrosis (%) | |||
| None | -- | -- | 34.6 |
| 1a: Zone 3 fibrosis Trichrome | -- | -- | 11.1 |
| 1b: Zone 3 fibrosis H & E | -- | -- | 2.5 |
| 1c: Portal fibrosis only | -- | -- | 7.4 |
| 2: Zone 3 and portal fibrosis | -- | -- | 11.1 |
| 3: Bridging Fibrosis | -- | -- | 16 |
| 4: Cirrhosis | -- | -- | 17.3 |
*
p<0.001 NAFLD vs lean;
**
P<.001 NAFLD vs lean/obese