Table 2.
Serum Atherogenic Risk Profile in Lean, Obese and NAFLD Cohorts.
| LEAN (N=81) |
OBESE (N=81) |
NAFLD (N=81) |
|
|---|---|---|---|
| TRADITIONAL PARAMETERS | |||
| Cholesterol-Total (mg/dL) | 198±38 | 185±42*** | 203±49 |
| HDL-C (mg/dL) | 63±16 | 53±18‡ | 55±15* |
| LDL-C (mg/dL) | 105±29 | 98±31 | 118±41** |
| Triglycerides (mg/dL) | 104±53 | 113±58 | 154±87** |
| LOW DENSITY LIPOPROTEIN | |||
| LDL-P (nmol/L) | 1432±456 | 1447±469 | 1717±684** |
| Small-density LDL-C (mg/dL) | 25.1±9.5 | 24.1±9.6 | 36.8±17.3** |
| % Small-density LDL | 24.1±9.6 | 24.8±7,5 | 32.6±15.7** |
| Small density LDL-P (nmol/L) | 591±388 | 652±355 | 870±654** |
| VERY LOW DENSITY LIPOPROTEIN | 89±22 | 87±23 | 101±31** |
| Apolipoprotein-B (mg/dL) | 1.4±1.5 | 2.1±2.3 | 3.2±3.1** |
| VLDL-P (nmol/L) | 43.4±4.9 | 45.1±5.5‡ | 47.1±5.2* |
| VLDL size (nm) | |||
| HIGH DENSITY LIPOPROTEIN | |||
| Apolipoprotein-A1 (mg/dL) | 168±32 | 154±34‡ | 148±30* |
| HDL-2 (mg/dL) | 15.4±6.7 | 13.3±6.8 | 12.7±6* |
| HDL-P (nmol/L) | 36.7±6.2 | 33.8±7.5‡ | 33.0±5.7 |
| INSULIN RESISTANCE | |||
| Free Fatty Acids (mmol/L) | 0.65±0.28 | 0.60±0.23 | 0.76±0.24** |
| Glucose (mg/dL) | 89±3 | 89±5 | 83±14** |
| Insulin (uU/mL) | 6.6±4.4 | 12.6±10.4‡ | 19.7±13.2** |
| Hemoglobin A1c (%) | 5.3±0.3 | 5.5±0.4‡ | 5.6±0.5** |
| IRHOMA | 1.45±0.95 | 2.75±2.16‡ | 4.36±3.13** |
| INFLAMMATORY | |||
| Fibrinogen (mg/dL) | 390±114 | 447±117‡ | 406±85*** |
| hs-C-Reactive Protein (mg/L) | 2.0±4.0 | 4.1±5.8‡ | 3.7±3.4* |
| Myeloperoxidase (pmol/L) | 388±113 | 473±148‡ | 445±123* |
| METABOLIC | |||
| Homocysteine (umol/L) | 11.7±3.8 | 11.3±3.4 | 13±3.5*** |
| MISCELLANEOUS | |||
| ApoB:Apo-A1 ratio | 0.56±0.20 | 0.59±0.20 | 0.70±0.26** |
| Lp(a)-mass | 34.3±37 | 49.8±51.4‡ | 23.1±26.5*** |
| Lp-PLA2 | 157±42 | 130±40‡ | 163±40*** |
‡
P<.01 lean vs obese,
*
P<.01 NAFLD vs lean;
**
P<.01 NAFLD vs lean/obese,
***
P <0.01 Obese vs. NAFLD