Table 3.

Serum Atherogenic Profile in Patients with NAFLD, NASH and cirrhosis.

	Simple Steatosis (N=32)	Steatohepatitis (N=35)	Cirrhosis (N=14)
DEMOGRAPHICS
Age (years)	53±13	56±13	61±8
BMI (kg/m2)	32.6±6.0	33.2±6.2	34.7±6.0
ALT (IU/mL)	61±42	51±37	41±17
AST (IU/mL)	49±38	42±25	48±21
Gender (%M)	13 (40.6%)	11 (31.4)	3 (21.4)
TRADITIONAL PARAMETERS
Cholesterol-Total (mg/dL)	202±40	204±56	171±30**
HDL-C (mg/dL)	58±22	49±13	49±11
LDL-C (mg/dL)	120±36	118±46	92±28**
Triglycerides (mg/dL)	147±73	160±98	109±39**
LOW DENSITY LIPOPROTEIN
LDL-P (nmol/L)	1619±570	1784±753	1327±601**
Small-density LDL-C (mg/dL)	36.8±17.3	36.7±17.5	23.0±12.1**
% Small-density LDL	31.8±13.5	33.1±17.3	24.1±6.4**
Small density LDL-P (nmol/L)	710±497	935±708	736±361
VERY LOW DENSITY LIPOPROTEIN
Apolipoprotein-B (mg/dL)	97±26	103±34	81±25**
VLDL-P (nmol/L)	3.3±3.7	3.1±2.9	1.9±1.3
VLDL size (nm)	46.3±7.8	47.5±3.2	45.8±3.8
HIGH DENSITY LIPOPROTEIN
Apolipoprotein-A1 (mg/dL)	154±26	144±31	136±49
HDL-2 (mg/dL)	12.5±5.3	12.8±6.1	15.1±9.4
INSULIN RESISTANCE
Adiponectin	12.4±7.9	9.7±5.4	11.4±6.7
Free Fatty Acids (mmol/L)	0.71±0.24	0.79±0.23	0.83±0.2
Glucose (mg/dL)	82±16	85±13	81±13
Insulin (uU/mL)	18.4±14.5	20.1±11.8	24±9
Hemoglobin A1c (%)	5.5±0.5	5.6±0.5	5.6±0.6
INFLAMMATORY
Fibrinogen (mg/dL)	411±81	403±89	426±86
hs-C-Reactive Protein (mg/L)	3.1±2.8	4.0±3.8	3.1±2.1
Myeloperoxidase (pmol/L)	423±112	458±131	454±81
METABOLIC
Homocysteine (umol/L)	12.9±3.3	13.0±3.8	14.0±3.8
MISCELLANEOUS
ApoB:Apo-A1 ratio	0.66±0.23	0.74±0.27	0.54±0.31**
Lp(a)-mass	28.2±31.3	19.4±22.3	28.4±32.9
Lp-PLA2	168±40	160±40	180±69

^*P<.01 NAFLD vs. NASH;

^**P<0.05 Cirrhosis vs No-Cirrhosis