Table 3.

Odds ratios from the adjusted multinomial regression models including traditional (Model 1), novel (Model 2), and bone metabolism (Model 3) risk factors of AVC. For the following continuous variables, the odds ratio is per standard deviation of the value: eGFR, age, waist circumference, total METs at baseline, LDL, HDL, and phosphate. The natural log of one plus the following continuous variables was used: hs-CRP, Lipoprotein a, total PTH, 24 hours urine protein. The following variables were from baseline measurements: Total Met, hsCRP, uric acid, homocysteine, Lipoprotein a, and total PTH.

	Unadjusted Model (n=1923)			Model 1: Traditional CV risk factors (n=1691)			Model 2: Nouel CV risk factors (n=1470)			Model 3: Markers of bone metabolism (n=1442)
	Total AVC			Total AVC			Total AVC			Total AVC
	>0-100	100+	p	>0-100	100+	p	>0-100	100+	p	>0 - 100	100+	p
eGFR using CRIC equation	0.84 (0.76, 0.94)	0.60 (0.53, 0.69)	<.001	1.08 (0.92, 1.27)	0.79 (0.65, 0.97)	0.015	1.14 (0.94, 1.40)	0.97 (0.76, 1.24)	0.297	1.12 (0.90, 1.39)	0.95 (0.72, 1.24)	0.41
Participant Age				2.87 (2.37, 3.48)	6.04 (4.64, 7.85)	<.001	3.03 (2.45, 3.74)	6.33 (4.72, 8.50)	<.001	3.15 (2.53, 3.93)	6.85 (5.04, 9.30)	<.001
Black				0.90 (0.66, 1.22)	0.56 (0.39, 0.80)	0.005	0.65 (0.46, 0.94)	0.36 (0.24, 0.55)	<.001	0.66 (0.45, 0.95)	0.38 (0.25, 0.59)	<.001
Female				1.21 (0.90, 1.65)	0.95 (0.67, 1.36)	0.3	1.20 (0.85, 1.69)	1.08 (0.72, 1.62)	0.59	1.14 (0.79, 1.63)	1.02 (0.67, 1.57)	0.775
Cardio-Vascular Disease				1.41 (1.04, 1.93)	2.17 (1.56, 3.03)	<.001	1.26 (0.89, 1.77)	2.00 (1.39, 2.90)	<.001	1.18 (0.84, 1.67)	1.92 (1.32, 2.79)	0.002
Current Smoker				0.99 (0.63, 1.56)	1.33 (0.80, 2.21)	0.485	0.91 (0.55, 1.50)	0.94 (0.51, 1.72)	0.927	0.91 (0.55, 1.52)	0.89 (0.48, 1.66)	0.911
Body Mass Index (kg/m^2)				1.01 (0.97, 1.06)	1.01 (0.96, 1.06)	0.807	1.01 (0.97, 1.06)	1.00 (0.95, 1.05)	0.813	1.01 (0.97, 1.06)	1.00 (0.95, 1.05)	0.779
Waist Circumference (cm)				0.98 (0.74, 1.29)	1.08 (0.79, 1.48)	0.801	0.93 (0.69, 1.25)	1.01 (0.72, 1.43)	0.85	0.92 (0.68, 1.25)	1.01 (0.71, 1.43)	0.822
Total MET sum (METhrs/week)				0.99 (0.86, 1.14)	0.96 (0.80, 1.15)	0.883	1.03 (0.89, 1.19)	0.96 (0.79, 1.17)	0.793	1.04 (0.89, 1.20)	0.95 (0.78, 1.17)	0.72
Diabetes				1.90 (1.42, 2.55)	1.86 (1.34, 2.60)	<.001	2.01 (1.46, 2.77)	1.82 (1.26, 2.64)	<.001	1.89 (1.36, 2.63)	1.87 (1.27, 2.74)	<.001
Systolic BP (mmHg)				1.00 (1.00, 1.01)	1.01 (1.00, 1.02)	0.009	1.01 (1.00, 1.02)	1.02 (1.01, 1.03)	0.001	1.01 (1.00, 1.02)	1.02 (1.01, 1.03)	0.001
High Cholesterol				1.66 (1.11, 2.49)	2.44 (1.41, 4.23)	0.002	1.98 (1.26, 3.09)	2.54 (1.41, 4.59)	<.001	2.04 (1.29, 3.22)	2.55 (1.39, 4.66)	<.001
Low-density Lipoprotein (mg/dL)				0.99 (0.85, 1.14)	1.16 (0.99, 1.37)	0.11	0.96 (0.82, 1.13)	1.16 (0.96, 1.39)	0.127	0.96 (0.82, 1.13)	1.13 (0.93, 1.36)	0.242
High-density Lipoprotein (mg/dL)				1.13 (0.98, 1.30)	0.92 (0.77, 1.10)	0.051	1.11 (0.95, 1.30)	0.93 (0.76, 1.13)	0.148	1.12 (0.95, 1.31)	0.94 (0.77, 1.15)	0.185
24-hour urine protein				1.05 (0.79, 1.40)	0.92 (0.66, 1.27)	0.704	1.01 (0.73, 1.40)	0.93 (0.63, 1.35)	0.886	0.96 (0.68, 1.34)	0.98 (0.66, 1.45)	0.966
High Sensitivity CRP							1.17 (0.97, 1.42)	1.36 (1.10, 1.69)	0.019	1.17 (0.97, 1.42)	1.34 (1.08, 1.67)	0.03
Uric Acid (mg/dL)							1.01 (0.93, 1.10)	1.06 (0.96, 1.18)	0.444	1.01 (0.92, 1.10)	1.08 (0.97, 1.20)	0.329
Total Plasma Homocysteine							1.01 (0.98, 1.04)	1.08 (1.04, 1.12)	<.001	1.01 (0.98, 1.05)	1.08 (1.04, 1.12)	<.001
Lipoprotein(a)(mg/dl)							1.12 (1.00, 1.27)	1.10 (0.96, 1.27)	0.139	1.13 (0.99, 1.27)	1.10 (0.95, 1.27)	0.15
Calcium (mg/dL)										0.77 (0.56, 1.06)	1.02 (0.71, 1.48)	0.186
Phosphate (mg/dL)										1.20 (1.01, 1.42)	1.06 (0.86, 1.30)	0.104
Total Parathyroid Hormone (pg/ml)										0.82 (0.63, 1.06)	0.83 (0.61, 1.11)	0.262