Table 4.
Odds ratio of aortic valve calcification associated with traditional, novel, and bone metabolism risk factors by race.
| Total AVC >0 - 100 | Total AVC 100+ | P-value | ||||
|---|---|---|---|---|---|---|
| Black (n=502) | Not Black (n=940) | Black(n=502) | Not Black (n=940) | Black | Not Black | |
| eGFR using CRIC equation | 1.00 (0.70, 1.43) | 1.22 (0.91, 1.63) | 0.93 (0.59, 1.45) | 0.90 (0.63, 1.30) | 0.941 | 0.208 |
| Participant Age | 3.76 (2.49, 5.68) | 2.86 (2.18, 3.74) | 7.36 (4.20, 12.89) | 6.90 (4.68, 10.19) | <.001 | <.001 |
| Female | 1.42 (0.75, 2.68) | 1.00 (0.63, 1.59) | 2.29 (1.09, 4.82) | 0.72 (0.41, 1.28) | 0.092 | 0.462 |
| Cardio-Vascular Disease | 1.42 (0.82, 2.46) | 1.12 (0.69, 1.81) | 1.23 (0.66, 2.29) | 2.55 (1.54, 4.23) | 0.459 | <.001 |
| Current Smoker | 1.19 (0.57, 2.48) | 0.72 (0.33, 1.55) | 1.12 (0.47, 2.65) | 0.61 (0.23, 1.60) | 0.892 | 0.525 |
| Body Mass Index (kg/m^2) | 1.02 (0.95, 1.10) | 1.00 (0.94, 1.06) | 0.99 (0.91, 1.08) | 0.98 (0.91, 1.05) | 0.744 | 0.785 |
| Waist Circumference (cm) | 0.90 (0.55, 1.48) | 1.00 (0.67, 1.49) | 1.07 (0.62, 1.85) | 1.17 (0.73, 1.89) | 0.826 | 0.764 |
| Total MET (METhrs/week) | 1.02 (0.81, 1.29) | 1.06 (0.86, 1.30) | 1.01 (0.75, 1.34) | 0.92 (0.69, 1.22) | 0.98 | 0.625 |
| Diabetes | 2.03 (1.16, 3.55) | 1.93 (1.25, 2.98) | 0.82 (0.42, 1.60) | 2.76 (1.66, 4.58) | 0.01 | <.001 |
| Systolic BP (mmHg) | 1.00 (0.98, 1.01) | 1.02 (1.01, 1.03) | 1.03 (1.01, 1.04) | 1.01 (1.00, 1.03) | 0.001 | 0.007 |
| High Cholesterol | 1.30 (0.59, 2.88) | 2.48 (1.39, 4.44) | 1.89 (0.71, 5.00) | 3.52 (1.56, 7.95) | 0.437 | <.001 |
| Low-density Lipoprotein (mg/dL) | 1.18 (0.90, 1.54) | 0.85 (0.69, 1.05) | 1.00 (0.72, 1.38) | 1.23 (0.96, 1.57) | 0.404 | 0.013 |
| High-density Lipoprotein (mg/dL) | 1.23 (0.94, 1.61) | 1.08 (0.87, 1.33) | 0.85 (0.61, 1.18) | 0.98 (0.75, 1.29) | 0.065 | 0.714 |
| 24-hour Urine Protein | 0.94 (0.52, 1.72) | 0.92 (0.60, 1.41) | 1.14 (0.57, 2.27) | 0.89 (0.54, 1.48) | 0.879 | 0.889 |
| High Sensitivity CRP | 1.06 (0.79, 1.44) | 1.26 (0.97, 1.65) | 1.08 (0.76, 1.54) | 1.53 (1.13, 2.08) | 0.883 | 0.022 |
| Uric Acid (mg/dL) | 1.03 (0.89, 1.19) | 0.97 (0.86, 1.10) | 1.09 (0.92, 1.29) | 1.08 (0.93, 1.25) | 0.618 | 0.344 |
| Total Plasma Homocysteine | 1.00 (0.94, 1.05) | 1.03 (0.98, 1.07) | 1.09 (1.03, 1.14) | 1.07 (1.02, 1.13) | 0.001 | 0.017 |
| Lipoprotein(a) (mg/dl) | 1.19 (0.92, 1.53) | 1.12 (0.97, 1.30) | 1.23 (0.89, 1.70) | 1.06 (0.90, 1.26) | 0.29 | 0.319 |
| Calcium (mg/dL) | 0.76 (0.45, 1.30) | 0.79 (0.51, 1.20) | 1.00 (0.55, 1.83) | 0.97 (0.59, 1.58) | 0.546 | 0.494 |
| Phosphate (mg/dL) | 1.18 (0.89, 1.56) | 1.25 (1.00, 1.56) | 0.98 (0.69, 1.39) | 1.10 (0.84, 1.44) | 0.443 | 0.143 |
| Total Parathyroid Hormone (pg/ml) | 0.82 (0.54, 1.25) | 0.83 (0.58, 1.19) | 0.69 (0.42, 1.15) | 0.93 (0.62, 1.39) | 0.337 | 0.599 |
For the following continuous variables, the odds ratio is per standard deviation of the value: eGFR, age, waist circumference, total metabolic equivalent (MET), LDL, HDL, and phosphate. The natural log of one plus the following continuous variables was used: hs-CRP, Lipoprotein a, total PTH, 24 hours urine protein. The following variables were from baseline measurements: Total METs, hsCRP, uric acid, homocysteine, Lipoprotein a, and total PTH.