Table 2.
Analysis of data among patients with no, mild and moderate to extensive fibrosis (Kruskal Wallis test)
| No fibrosis (n = 12) | Mild fibrosis (n = 20) | Moderate to extensive fibrosis (n = 11) | P | |
| Median (min-max) | Median (min-max) | Median (min-max) | ||
| Age at biopsy | 9 (3.5 yr-13 yr) | 7.3 (1 yr-19 yr) | 11 (2 mo-18 yr) | 0.394 (NS) |
| Duration from exposure to biopsy (mo) (n = 29) | 43.8 | 36 | 12 | 0.627 (NS) |
| (12-144) | (12-120) | (2.4-144) | ||
| Duration from first detected ALT elevation to biopsy (mo) | 12 | 6 | 1.2 | 0.015 (S) |
| (0-24) | (0-24) | (0-7.2) | ||
| Duration from exposure to first detected ALT elevation (mo) | 30 | 18 | 12 | 0.411 (NS) |
| (n = 29) | (12-132) | (0-119) | (1.2-141) | |
| Total bilirubin (mg/dL) | 1.65 | 0.8 | 1.5 | 0.270 (NS) |
| (0.-5.2) | (0.3-4.3) | (0.4-11) | ||
| Direct bilirubin (mg/dL) | 0.3 | 0.2 | 0.5 | 0.048 (S) |
| (0.1-2.5) | (0.1-1.3) | (0.1-10) | ||
| ALT (IU/L) | 77 | 88 | 97 | 0.649 (NS) |
| (17-367) | (16-432) | (30-1200) | ||
| AST (IU/L) | 69 | 84 | 96 | 0.912 (NS) |
| (27-273) | (28-415) | (26-927) | ||
| Albumin (mg/dL) | 3.6 | 4.2 | 3.1 | 0.119 (NS) |
| (2.9-4.7) | (3.1-5.3) | (2.8-4.7) | ||
| Prothrombin Concentration (%) | 80 | 87 | 80 | 0.458 (NS) |
| (66-100) | (60-100) | (55-97) | ||
| Platelets count (thousands/mm3) | 333 | 266 | 306 | 0.329 (NS) |
| (110-284) | (138-396) | (95-302) | ||
| HAI | 5 | 5 | 4 | 0.574 (NS) |
| (0-11) | (0-10) | (0-9) | ||
| TIS | 9 | 3 | 9 | 0.49 (NS) |
| (0-27) | (0-18) | (0-18) | ||
| Steatosis | n = 12 | n = 20 | n = 11 | |
| None (n = 30) | 10 | 13 | 7 | 0.61 (NS) |
| Mild (n = 5) | 0 | 4 | 1 | |
| Moderate (n = 6) | 2 | 2 | 2 | |
| Severe (n = 2) | 0 | 1 | 1 |