Table 5. Hematological values of Beagle dogs administered with Lithospermum erythrorhizon hexane extract or its vehicle.
| Dose (mg/kg/day) | Main group | Recovery group | |||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Control | 30 | 100 | 300 | Control | 300 | ||
|
| |||||||
| Males | |||||||
| RBC (× 106 cells/μL) | 6.89 ± 0.57 | 6.92 ± 0.55 | 6.96 ± 0.11 | 6.57 ± 0.34 | 6.82 ± 0.14 | 6.62 ± 0.06 | |
| HGB (g/dL) | 15.8 ± 1.1 | 15.6 ± 0.9 | 15.6 ± 0.7 | 15.3 ± 0.9 | 16.1 ± 0.9 | 15.6 ± 0.4 | |
| HCT (%) | 43.9 ± 3.3 | 42.7 ± 1.8 | 43.2 ± 1.6 | 41.8 ± 2.1 | 44.1 ± 1.6 | 42.6 ± 1.0 | |
| Reti (%) | 0.79 ± 0.14 | 0.92 ± 0.25 | 0.68 ± 0.11 | 0.80 ± 0.36 | 1.16 ± 0.13 | 0.77 ± 0.28 | |
| RBC index | MCV (fL) | 63.8 ± 1.3 | 61.8 ± 2.6 | 62.1 ± 1.4 | 63.6 ± 1.3 | 64.7 ± 0.9 | 64.4 ± 1.9 |
| MCH (pg) | 22.9 ± 0.5 | 22.6 ± 1.0 | 22.5 ± 0.6 | 23.2 ± 0.6 | 23.5 ± 0.8 | 23.5 ± 0.7 | |
| MCHC (g/dL) | 35.9 ± 0.4 | 36.5 ± 0.8 | 36.3 ± 0.5 | 36.4 ± 0.3 | 36.4 ± 0.8 | 23.5 ± 0.7 | |
| PLT (× 103 cells/μL) | 244 ± 35 | 273 ± 8 | 274 ± 51 | 309 ± 86 | 215 ± 27 | 255 ± 16 | |
| WBC (× 103 cells/μL) | 9.08 ± 1.99 | 10.19 ± 0.60 | 10.59 ± 2.44 | 11.51 ± 1.01 | 7.90 ± 1.24 | 10.83 ± 0.71 | |
| WBC | NEU | 53.1 ± 6.8 | 49.8 ± 11.5 | 53.5 ± 10.0 | 57.5 ± 4.0 | 50.4 ± 5.3 | 35.7 ± 6.6 |
| differential | LYM | 34.6 ± 5.5 | 37.4 ± 9.5 | 32.3 ± 6.5 | 31.8 ± 2.5 | 35.7 ± 6.6 | 33.2 ± 5.5 |
| counting (%) | MONO | 5.9 ± 1.4 | 7.9 ± 2.2 | 7.2 ± 3.0 | 6.0 ± 1.6 | 5.4 ± 0.7 | 7.0 ± 0.2 |
| EOS | 5.6 ± 2.5 | 3.9 ± 0.5 | 6.0 ± 1.2 | 3.6 ± 2.0 | 7.6 ±1.8. | 7.0 ± 0.2 | |
| BASO | 0.6 ± 0.1 | 0.7 ± 0.2 | 0.7 ± 0.2 | 0.6 ± 0.3 | 0.7 ± 0.1 | 0.8 ± 0.3 | |
| PT (sec) | 10.5 ± 1.1 | 9.8 ± 0.4 | 9.6 ± 0.1 | 9.7 ± 0.4 | 10.0 ± 0.7 | 9.7 ± 0.1 | |
| APTT (sec) | 16.0 ± 1.1 | 15.4 ± 1.2 | 14.4 ± 1.5 | 15.0 ± 0.4 | 14.9 ± 3.3 | 15.3 ± 0.5 | |
| Females | |||||||
| RBC (× 106 cells/μL) | 6.60 ± 0.26 | 6.96 ± 0.62 | 6.37 ± 0.17 | 6.39 ± 0.59 | 7.60 ± 0.09 | 7.23 ± 0.08 | |
| HGB (g/dL) | 14.9 ± 0.8 | 15.8 ± 1.5 | 14.4 ± 0.9 | 15.0 ± 1.4 | 17.5 ± 0.6 | 17.0 ± 1.0 | |
| HCT (%) | 41.4 ± 1.6 | 43.3 ± 3.3 | 40.0 ± 2.4 | 41.4 ± 3.5 | 47.6 ± 0.8 | 45.6 ± 2.0 | |
| Reti (%) | 0.64 ± 0.19 | 0.61 ± 0.11 | 0.83 ± 0.20 | 0.65 ± 0.25 | 0.83 ± 0.19 | 1.13 ± 0.16 | |
| RBC index | MCV (fL) | 62.7 ± 1.6 | 62.3 ± 1.0 | 62.7 ± 2.3 | 64.9 ± 2.9 | 62.7 ± 1.8 | 63.1 ± 2.1 |
| MCH (pg) | 22.6 ± 0.9 | 22.7 ± 0.5 | 22.6 ± 0.8 | 23.5 ± 1.2 | 23.1 ± 1.1 | 23.6 ± 1.2 | |
| MCHC (g/dL) | 36.0 ± 0.7 | 36.4 ± 0.7 | 36.0 ± 0.3 | 36.1 ± 0.4 | 36.9 ± 0.6 | 37.3 ± 0.6 | |
| PLT (× 103 cells/μL) | 257 ± 52 | 338 ± 42* | 280 ± 14 | 307 ± 25 | 224 ± 124 | 302 ± 21 | |
| WBC (× 103 cells/μL) | 8.75 ± 2.01 | 9.26 ± 1.23 | 10.68 ± 2.21 | 8.85 ± 1.73 | 6.95 ± 0.73 | 8.94 ± 0.16 | |
| WBC | NEU | 52.2 ± 5.8 | 57.0 ± 10.2 | 60.6 ± 0.3 | 56.5 ± 10.0 | 40.9 ± 1.8 | 50.4 ± 4.9 |
| differential | LYM | 37.0 ± 7.8 | 33.6 ± 9.5 | 29.7 ± 0.8 | 33.7 ± 9.7 | 47.7 ± 6.4 | 37.4 ± 7.6 |
| counting (%) | MONO | 5.2 ± 0.7 | 5.1 ± 1.4 | 5.8 ± 1.9 | 5.8 ± 3.0 | 6.2 ± 2.8 | 4.3 ± 0.2 |
| EOS | 4.8 ± 3.3 | 5.1 ± 1.4 | 5.8 ± 1.9 | 5.8 ± 0.7 | 3.8 ± 2.6 | 6.8 ± 2.6 | |
| BASO | 0.5 ± 0.4 | 0.9 ± 0.6 | 0.4 ± 0.1 | 0.6 ± 0.2 | 1.1 ± 0.5 | 0.9 ± 0.1 | |
| PT (sec) | 9.7 ± 0.1 | 9.7 ± 0.2 | 11.2 ± 1.8 | 9.6 ± 0.0 | 9.9 ± 0.2 | 9.6 ± 0.0 | |
| APTT (sec) | 17.4 ± 1.7 | 15.5 ± 0.3 | 16.4 ± 1.3 | 15.6 ± 1.2 | 16.1 ± 0.3 | 14.2 ± 1.5 | |
Significantly different from the control by Dunnett’s t-test, *: p < 0.05.