Table 7. Blood chemical values of Beagle dogs administered with Lithospermum erythrorhizon hexane extract or its vehicle.
| Dose (mg/kg/day) | Main group | ||||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Control | 30 | 100 | 300 | Control | 300 | ||
|
| |||||||
| Males | |||||||
| ALT (U/L) | 28.8 ± 2.4 | 22.1 ± 0.9 | 210.0 ± 5.0 | 24.3 ± 5.7 | 30.4 ± 4.7 | 23.6 ± 4.1 | |
| AST (U/L) | 30.7 ± 2.1 | 29.8 ± 3.0 | 24.3 ± 4.6 | 29.1 ± 7.0 | 31.5 ± 0.4 | 28.0 ± 2.1 | |
| ALP (U/L) | 388.9 ± 89.9 | 425.6 ± 74.4 | 430.1 ± 77.5 | 567.3 ± 200.0 | 404.0 ± 169.4 | 575.3 ± 108.8 | |
| GGT (U/L) | 4.13 ± 0.28 | 3.99 ± 0.28 | 4.37 ± 0.51 | 4.26 ± 0.48 | 4.02 ± 0.34 | 3.71 ± 0.25 | |
| Glu (mg/dL) | 102 ± 4 | 102 ± 7 | 105 ± 7 | 108 ± 9.0 | 98 ± 1 | 116 ± 6 | |
| BUN (mg/dL) | 10.3 ± 1.6 | 11.3 ± 1.9 | 12.5 ± 2.4 | 9.0 ± 0.7 | 10.6 ± 1.3 | 9.5 ± 0.6 | |
| Crea (mg/dL) | 0.74 ± 0.03 | 0.76 ± 0.12 | 0.76 ± 0.12 | 0.65 ± 0.05 | 0.76 ± 0.02 | 0.69 ± 0.06 | |
| T-Bili (mg/dL) | 0.03 ± 0.00 | 0.10 ± 0.03# | 0.07 ± 0.03 | 0.15 ± 0.07# | 0.02 ± 0.01 | 0.05 ± 0.03 | |
| T-Chol (mg/dL) | 170 ± 6 | 107 ± 3 | 176 ± 74 | 150 ± 23 | 161 ± 1 | 161 ± 1 | |
| TG (mg/dL) | 28 ± 8 | 29 ± 3 | 45 ± 4 | 51 ± 13** | 24 ± 2 | 24 ± 2 | |
| TP (mg/dL) | 5.2 ± 0.2 | 5.2 ± 0.2 | 5.3 ± 0.2 | 5.1 ± 0.1 | 5.2 ± 0.1 | 5.1 ± 0.2 | |
| Alb (%) | 47.4 ± 2.2 | 47.7 ± 2.9 | 45.9 ± 1.7 | 47.0 ± 2.2 | 45.0 ± 3.2 | 48.3 ± 1.6 | |
| Globulin-α1 (%) | 11.1 ± 0.5 | 9.1 ± 0.5* | 11.1 ± 1.5 | 10.7 ± 0.6 | 11.6 ± 0.7 | 11.9. ± 0.0 | |
| Globulin-α2 (%) | 12.6 ± 0.6 | 12.3 ± 0.7 | 13.3 ± 0.8 | 12.7 ± 0.7 | 12.4 ± 1.3 | 11.9 ± 0.1 | |
| Globulin-β (%) | 18.6 ± 0.8 | 21.0 ± 1.7* | 19.7 ± 0.4 | 19.8 ± 1.0 | 20.1 ± 2.0 | 18.7 ± 0.6 | |
| Globulin-γ (%) | 10.4 ± 2.0 | 9.8 ± 1.0 | 10.0 ± 0.3 | 9.8 ± 0.7 | 11.0 ± 0.6 | 9.3 ± 0.8 | |
| A/G ration | 0.90 ± 0.08 | 0.92 ± 0.11 | 0.85 ± 0.06 | 0.89 ± 0.07 | 0.82 ± 0.10 | 0.94 ± 0.06 | |
| P (mg/dL) | 6.41 ± 0.42 | 5.48 ± 0.72* | 6.02 ± 0.23 | 5.67 ± 0.25* | 6.62 ± 0.60 | 6.29 ± 0.01 | |
| Ca (mg/dL) | 10.8 ± 0.4 | 10.9 ± 0.2 | 11.2 ± 0.2 | 10.6 ± 0.1 | 10.8 ± 0.4 | 10.5 ± 0.2 | |
| Na (mg/dL) | 144.2 ± 1.0 | 143.7 ± 0.72 | 143.7 ± 1.0 | 143.5 ± 0.9 | 144.3 ± 0.7 | 144.2 ± 0.6 | |
| K (mg/dL) | 4.75 ± 0.26 | 4.74 ± 0.20 | 4.68 ± 0.20 | 4.85 ± 0.42 | 4.87 ± 0.06 | 4.77 ± 0.08 | |
| Cl (mg/dL) | 111.9 ± 1.9 | 111.7 ± 0.9 | 111.3 ± 0.7 | 111.6 ± 1.6 | 115.0 ± 0.6 | 112.3 ± 0.4 | |
| Females | |||||||
| ALT (U/L) | 29.1 ± 1.1 | 20.7 ± 6.9 | 24.9 ± 6.0 | 23.1 ± 2.6# | 29.7 ± 2.1 | 28.7 ± 0.4 | |
| AST (U/L) | 27.9 ± 2.1 | 23.2 ± 3.8 | 26.1 ± 3.1 | 28.5 ± 4.8 | 29.6 ± 0.6 | 37.8 ± 6.0 | |
| ALP (U/L) | 388.4 ± 124.2 | 290.2 ± 77.0 | 341.1 ± 91.4 | 330.0 ± 100.4 | 417.9 ± 89.4 | 0421.8 ± 246.6 | |
| GGT (U/L) | 3.68 ± 0.27 | 3.69 ± 0.52 | 3.55 ± 0.51 | 3.88 ± 0.56 | 3.53 ± 0.15 | 5.12 ± 1.34 | |
| Glu (mg/dL) | 104 ± 9 | 99 ± 3 | 108 ± 6 | 96 ± 9 | 111 ± 6 | 100 ± 2 | |
| BUN (mg/dL) | 10.0 ± 1.3 | 10.2 ± 0.9 | 9.1 ± 1.6 | 9.7 ± 0.7 | 12.1 ± 2.3 | 11.6 ± 1.3 | |
| Crea (mg/dL) | 0.75 ± 0.07 | 0.72 ± 0.05 | 0.69 ± 0.10 | 0.69 ± 0.08 | 0.83 ± 0.06 | 0.77 ± 0.11 | |
| T-Bili (mg/dL) | 0.05 ± 0.03 | 0.09 ± 0.03 | 0.14 ± 0.05 | 0.27 ± 0.14# | 0.05 ± 0.01 | 0.04 ± 0.01 | |
| T-Chol (mg/dL) | 129 ± 21 | 131 ± 24 | 141 ± 35 | 124 ± 21 | 127 ± 7 | 163 ± 40 | |
| TG (mg/dL) | 25 ± 6 | 31 ± 5 | 36 ± 13 | 47 ± 11** | 21 ± 3 | 39 ± 4 | |
| TP (mg/dL) | 4.9 ± 0.2 | 4.9 ± 0.4 | 5.2 ± 0.2 | 5.0 ± 0.3 | 5.1 ± 0.1 | 5.4 ± 0.1 | |
| Alb (%) | 50.9 ± 2.4 | 52.0 ± 2.0 | 49.2 ± 3.4 | 51.2 ± 1.2 | 52.2 ± 1.3 | 48.8 ± 0.1 | |
| Globulin-α1 (%) | 10.6 ± 1.0 | 10.7 ± 0.6 | 10.9 ± 1.5 | 9.6 ± 0.5 | 10.4 ± 0.9 | 11.7 ± 0.8 | |
| Globulin-α2 (%) | 10.6 ± 1.0 | 12.0 ± 2.0 | 11.2 ± 1.0 | 11.3 ± 0.2 | 10.5 ± 0.6 | 11.8 ± 0.8 | |
| Globulin-β (%) | 17.4 ± 1.4 | 17.4 ± 0.9 | 19.7 ± 2.3 | 18.5 ± 0.7 | 17.6 ± 0.1 | 18.8 ± 0.3 | |
| Globulin-γ (%) | 10.5 ± 1.7 | 9.0 ± 1.6 | 9.0 ± 1.6 | 9.4 ± 0.6 | 9.4 ± 0.1 | 9.0 ± 1.4 | |
| A/G ration | 1.04 ± 0.10 | 1.09 ± 0.09 | 0.98 ± 0.14 | 1.05 ± 0.05 | 1.09 ± 0.06 | 0.96 ± 0.06 | |
| P (mg/dL) | 5.77 ± 0.51 | 6.52 ± 0.37 | 5.92 ± 0.07 | 5.50 ± 0.67 | 6.64 ± 0.34 | 5.97 ± 1.34 | |
| Ca (mg/dL) | 10.4 ± 0.2 | 11.0 ± 0.1** | 10.7 ± 0.3 | 10.3 ± 0.2 | 10.8 ± 0.1 | 10.8 ± 0.7 | |
| Na (mg/dL) | 143.0 ± 1.9 | 144.5 ± 0.4 | 144.6 ± 0.8 | 144.0 ± 2.0 | 142.2 ± 1.4 | 145.3 ± 1.6 | |
| K (mg/dL) | 4.63 ± 0.41 | 4.89 ± 0.25 | 4.45 ± 0.04 | 4.56 ± 0.41 | 5.01 ± 0.45 | 4.69 ± 0.01 | |
| Cl (mg/dL) | 110.8 ± 2.4 | 111.3 ± 1.1 | 110.9 ± 1.7 | 112.0 ± 2.6 | 111.0 ± 0.2 | 111.9 ± 3.1 | |
Significantly different from the control by Dunnett’s t-test : * p < 0.05, **p < 0.01.
Significantly different from the control by Steel’s test: # p < 0.05.