Table 9. Absolute and relative organ weight in female Beagle dogs.
| Dose (mg/kg/day) | Main group | Recovery group | |||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Control | 30 | 100 | 300 | Control | 300 | ||
|
| |||||||
| Brain (g) | 73.0 ± 10.0 | 73.5 ± 4.6 | 68.0 ± 3.7 | 75.2 ± 5.8 | 74.2 ± 4.4 | 75.9 ± 6.6 | |
| Pituitary (mg) | 59.5 ± 1.3 | 62.5 ± 5.0 | 64.5 ± 3.5 | 62.0 ± 1.5 | 61.4 ± 1.6 | 73.6 ± 22.4 | |
| Thyroid (g) | 0.731 ± 0.185 | 0.719 ± 0.251 | 0.779 ± 0.204 | 0.630 ±0.109 | 0.886 ± 0.190 | 0.854 ± 0.016 | |
| Thymus (g) | 6.30 ± 3.10 | 7.71 ± 6.26 | 5.86 ± 1.13 | 4.45 ± 1.97 | 14.06 ± 6.580 | 5.67 ± 0.43 | |
| Heart (g) | 55.2 ± 58.3 | 58.3 ± 9.8 | 58.1 ± 8.4 | 54.8 ± 6.5 | 62.7 ± 3.0 | 57.9 ± 5.2 | |
| Liver (g) | 182 ± 31 | 191 ± 21 | 216 ± 35 | 179 ± 13 | 187 ± 0 | 197 ± 31 | |
| Spleen (g) | 24.4 ± 0.6 | 25.8 ± 5.4 | 25.3 ± 2.9 | 24.2 ± 5.1 | 28.1 ± 1.3 | 22.2 ± 4.0 | |
| Kidney (g) | 33.3 ± 2.3 | 34.0 ± 2.4 | 34.2 ± 3.5 | 34.1 ± 3.5 | 31.4 ± 0.7 | 36.1 ± 2.7 | |
| Adrenal (g) | 1.023 ± 0.204 | 1.103 ± 0.058 | 1.081 ± 0.198 | 1.096 ± 0.090 | 1.052 ± 0.111 | 1.142 ± 0.030 | |
| Ovary (g) | 0.512 ± 0.054 | 0.511 ± 0.042 | 0.631 ± 631* | 0.491 ± 0.038 | 0.556 ± 0.043 | 0.497 ± 0.021 | |
| Uterus (g) | 2.29 ± 1.05 | 1.20 ± 1.78 | 1.78 ± 1.0 | 1.69 ± 1.22 | 2.31 ± 0.60 | 1.70 ± 1.34 | |
|
| |||||||
| Dose (mg/kg/day) | Main group | Recovery group | |||||
|
|
|
||||||
| Control | 30 | 100 | 300 | Control | 300 | ||
|
| |||||||
| Brain (%) | 0.95 ± 0.15 | 0.96 ± 0.03 | 0.91 ± 0.09 | 1.07 ± 0.17 | 0.90 ± 0.11 | 0.99 ± 0.04 | |
| Pituitary (‰) | 0.0078 ± 0.0006 | 0.0082 ± 0.0007 | 0.0086 ± 0.0003 | 0.0088 ± 0.0011 | 0.0074 ± 0.0003 | 0.0095 ± 0.0016 | |
| Thyroid (‰) | 0.095 ± 0.026 | 0.095 ± 0.036 | 0.105 ± 0.032 | 0.088 ± 0.007 | 0.108 ± 0.030 | 0.112 ± 0.017 | |
| Thymus (‰) | 0.808 ± 0.349 | 1.006 ± 0.809 | 0.786 ± 0.165 | 0.620 ± 0.251 | 1.675 ± 0.688 | 0.740 ± 0.042 | |
| Heart (%) | 0.72 ± 0.05 | 0.76 ± 0.11 | 0.78 ± 0.11 | 0.77 ± 0.02 | 0.76 ± 0.01 | 0.76 ± 0.04 | |
| Liver (%) | 2.39 ± 0.53 | 2.50 ± 0.19 | 2.90 ± 0.55 | 2.54 ± 0.38 | 2.26 ± 0.14 | 2.56 ± 0.06 | |
| Spleen (%) | 0.32 ± 0.02 | 0.34 ± 0.06 | 0.34 ± 0.04 | 0.34 ± 0.07 | 0.38 ± 0.01 | 0.29 ± 0.01 | |
| Kidney (%) | 0.44 ± 0.05 | 0.45 ± 0.02 | 0.46 ± 0.06 | 0.48 ± 0.02 | 0.128 ± 0.022 | 0.47 ± 0.03 | |
| Adrenal (‰) | 0.135 ± 0.035 | 0.145 ± 0.007 | 0.145 ± 0.029 | 0.156 ± 0.026 | 0.067 ± 0.001 | 0.150 ± 0.016 | |
| Ovary (‰) | 0.067 ± 0.009 | 0.067 ± 0.006 | 0.084 ± 0.009 | 0.069 ± 0.006 | 0.067 ± 0.001 | 0.065 ± 0.006 | |
| Uterus (‰) | 0.304 ± 0.153 | 0.157 ± 0.090 | 0.235 ± 0.135 | 0.230 ± 0.161 | 0.276 ± 0.055 | 0.212 ± 0.146 | |
Significantly different from the control by Dunnett’s t-test: * p < 0.05.