Table 10. Toxicokinetic parameters for acetylshikonin in dog plasma on Day 1 and Day 28.

Sex	Dose (mg/kg/day)	Phase	Toxicokinetic parameters
			AUClast (ng · hr/mL)	Cmax (ng/mL)	Tmax (hr)	t1/2 (hr)
Males	30	Day 1	98.06	31.33	0.67	2.49
		Day 28	413.06	42.37	1.50	11.51
	100	Day 1	260.32	37.50	0.75	5.25
		Day 28	1202.06	88.17	0.83	12.74
	300	Day 1	138.46	37.40	1.00	4.91
		Day 28	1427.68	142.67	1.67	12.46
Females	30	Day 1	502.42	60.70	3.33	6.90
		Day 28	452.89	44.67	2.33	16.31
	100	Day 1	356.48	43.80	1.58	8.77
		Day 28	1156.48	82.07	2.25	15.11
	300	Day 1	361.67	56.20	1.08	6.93
		Day 28	1330.31	120.10	1.50	17.17