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. 2015 Jan 20;23(4):737–745. doi: 10.1038/mt.2014.242

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Copyright © 2015 The American Society of Gene & Cell Therapy

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Schematic representation of self-inactivating perforin lentiviral vectors (LV). Plasmid configuration is shown. Δ marks SIN deletion with partially deleted U3 of 3′ long terminal repeat. ppt, central polypurine tract; SD/SA, splice donor/splice acceptor; ψ, packaging signal; PGK, phosphoglycerate kinase promoter; PRF, perforin promoter; IRES, internal ribosomal entry site; WPRE, woodchuck hepatitis virus posttranscriptional regulatory element; U3/R/U5, LTR elements.