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. 2015 Jan 20;23(4):656–666. doi: 10.1038/mt.2014.247

Figure 1.

Figure 1

miR-125a-5p is induced by histone deacetylase inhibitors (HDACi). (a) MiRNA profiles were examined in Trichostatin A-treated R2N1d and MDA-MB-231 cells. (b) Differentially expressed miRNAs (>10-fold) in the Trichostatin A (TSA)-treated cells relative to the control cells (n = 3). (c) R2N1d cells were treated with different concentrations of the HDACi Trichostatin A (0, 0.5, 1, and 2 µmol/l), valproic acid (0, 3.5, 7, and 14 µmol/l), sodium butyrate (0, 1.5, 3, and 6 µmol/l), splitomycin (0, 0.5, 1, and 2 µmol/l), apicidin (0, 0.75, 1.5, and 3 µmol/l), or M344 (0, 0.5, 1, and 2 µmol/l), and miR-125a-5p expression was detected with qRT-PCR 48 hours post-treatment. Values are the mean ± standard deviation (SD) of three experiments.