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. 2015 Feb 10;23(4):717–727. doi: 10.1038/mt.2015.10

Figure 3.

Figure 3

Knockdown of miR-197 promotes tumorigenicity, pulmonary metastasis, and chemoresistance in vivo. (a) The bioluminescent change emitted from the whole bodies of the mice bearing PC14-miR-197-TuD-luc or PC14-TuD-NC-luc cells (10 mice per group) (P = 0.005) (left graph) and representative bioluminescence images of lung tumor growth on days 7 and 28 (right panel). (b) Representative pictures of murine whole lung (left) and hematoxylin/eosin (HE) staining of the right lung are presented (right graph) (scale bar = 100 μm). Arrows indicate primary lung nodules, and triangles indicate the surface of metastatic nodules. The number of visible surface metastatic lesions in mice (10 mice per group) was significantly increased in the miR-197-attenuated group (P = 0.039). (c) The ratio of lung weights to total body weight in mice (10 mice per group) (P = 0.006). (d) The bioluminescent change emitted from the whole bodies of the mice bearing PC14-miR-197-TuD-luc or PC14-TuD-NC-luc cells (10 mice per group) after repeated intraperitoneal injections (IP injections) of CDDP (P = 0.016). (e) Representative bioluminescence images of lung tumor growth in each group after repeated administration of CDDP. (f) The overall survival rates in each group were estimated by the Kaplan–Meier method (P = 0.036). CDDP, cisplatin.