Table 3.
Consensus criteria for sepsis-associated organ dysfunction1
| Organ System | Criteria for dysfunction |
|---|---|
| Cardiovascular | Hypotension (<5th percentile for age) despite >40ml/kg fluid bolus in 1 hr or Vasoactive requirement to maintain BP despite >40ml/kg fluid bolus in 1 hr or Two or more signs of abnormal perfusion (increased lactate, metabolic acidosis, decreased urine output (<0.5mL/kg/hr), capillary refill >5 sec) |
| Respiratory | PaO2/FiO2 <300 Hypercarbia (PaCo2 > 65 mm Hg or increase of ≥20 mm Hg from baseline) Required FiO2 >50% to maintain SpO2 ≥92% Need for non-elective invasive or non-invasive mechanical ventilation |
| Neurologic | Altered mental status defined as absolute GCS < 11 or decrease in GCS ≥3 from baseline |
| Hematologic | Platelet count <80,000/mm3 or decline of 50% from baseline INR > 2.0 |
| Renal | Serum creatinine ≥2 times upper limit of normal for age Two-fold increase from baseline serum creatinine |
| Hepatic | Total bilirubin >4mg/dL ALT more than 2 times the upper limit of normal for age |
BP, blood pressure, GCS, glascow coma scale, ALT, alanine aminotransferase
1
Adapted from Goldstein 2005