Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Mutat Res Genet Toxicol Environ Mutagen. 2015 Mar 12;782:51–56. doi: 10.1016/j.mrgentox.2015.03.007

Figure 1. Schematic of DBC bioactivation to DBC-11,12-diol-13,14-epoxide (DBCDE) by cytochrome P450 1B1 and EPHX1.

Figure 1

In the presence of DNA DBCDE binds covalently to DNA preferentially at the N6-position of deoxyadenosine forming the major adducts (−)-anti-cis-DBCDE-dA and (−)-anti-trans-DBCDE-dA. Location of stable 15N isotopes incorporated into the internal standards are shown in red.