Figure 4.

Dynamic pO₂ changes assessed using FREDOM. A. pO₂ maps of a representative tumor during baseline air breathing; 20 mins after switch to O₂-breathing; 2 hours after administration of OXi8007 (350 mg/kg), while continuing to breathe O₂ and after final switch back to air (left to right). B. Histogram showing pO₂ distributions at the four stages. Mean pO₂ and hypoxic fractions (HF₅ and HF₁₀) were respectively: baseline air-breathing (three dynamics), 47 Torr, 4%, 5%; baseline O₂-breathing (last three dynamics before VDA administration), 228 Torr, 0.7%, 0.7%; O₂-breathing two hours post OXi8007 administration (last five dynamics with stable pO₂ measurements before switching gas back to air), 58 Torr, 5%, 7%; air-breathing post OXi8007 (last three dynamics with stable pO₂ measurements), 12 Torr, 29%, 40%.