Table 2.
Hazard ratios for mortality associated with elevated body mass index in patients with and without diabetes
| No diabetes (n=2864) | Diabetes (n=1190) | ||||
|---|---|---|---|---|---|
| HR [95% CI] | p-value | HR [95% CI] | p-value | ||
| Unadjusted model | Normal weight | 1.0 | 1.0 | ||
| Overweight | 0.74 [0.59-0.93] | 0.0097 | 0.76 [0.56-1.02] | 0.0707 | |
| Obesity | 0.62 [0.46-0.85] | 0.0023 | 0.79 [0.58-1.09] | 0.1495 | |
| Minimal modela | Normal weight | 1.0 | 1.0 | ||
| Overweight | 0.72 [0.57-0.90] | 0.0040 | 0.80 [0.59-1.08] | 0.1467 | |
| Obesity | 0.64 [0.47-0.86] | 0.0036 | 0.91 [0.77-1.31] | 0.5691 | |
| Parsimonious model | Normal weight | 1.0 | 1.0 | ||
| Overweight | 0.73 [0.58-0.93]b | 0.0087 | 0.83 [0.61-1.13]c | 0.2383 | |
| Obesity | 0.64 [0.47-0.87]b | 0.0043 | 0.98 [0.71-1.36]c | 0.8914 | |
HR=Hazard Ratio, CI=Confidence Interval, BMI=Body Mass Index.
aAdjusted for sex and age.
bAdjusted for sex, age, stroke, smoking, re-infarction, left ventricular ejection fraction (<30% versus ≥30%), any reperfusion treatment (coronary artery bypass surgery, percutaneous coronary intervention (PCI) or thrombolysis), beta-blockers (medication prior AMI), all four medications at discharge (antiplatelet agents, beta-blockers, ACEIs/ARBs (Angiotensin-converting enzyme inhibitors/Angiotensin receptor blockers), statins).
cAdjusted for sex, age, hyperlipidemia, re-infarction, any reperfusion treatment, statins (medication prior AMI), all four medications at discharge.