Table 3.
Hazard ratios for mortality associated with elevated body mass index in patients with and without diabetes stratified by prescribed medications before and after myocardial infarction
| No diabetes (n=2864) | Diabetes (n=1190) | ||||
|---|---|---|---|---|---|
| HR [95% CI] | p-value | HR [95% CI] | p-value | ||
| Statins prior AMI | Normal weight | 1.0 | 1.0 | ||
| Overweight | 0.81 [0.44-1.52]a | 0.5179 | 0.51 [0.29-0.89]b | 0.0180 | |
| Obesity | 0.59 [0.26-1.35]a | 0.2115 | 0.82 [0.46-1.47]b | 0.5102 | |
| No statins prior AMI | Normal weight | 1.0 | 1.0 | ||
| Overweight | 0.71 [0.55-0.92]a | 0.0082 | 1.04 [0.71-1.52]b | 0.8456 | |
| Obesity | 0.66 [0.47-0.92]a | 0.0131 | 1.09 [0.73-1.64]b | 0.6697 | |
| Four medications at dischargec | Normal weight | 1.0 | 1.0 | ||
| Overweight | 0.76 [0.56-1.03]e | 0.0805 | 0.52 [0.34-0.80]f | 0.0027 | |
| Obesity | 0.56 [0.37-0.86]e | 0.0072 | 0.82 [0.54-1.26]f | 0.3745 | |
| Less than four medications at discharged | Normal weight | 1.0 | 1.0 | ||
| Overweight | 0.67 [0.47-0.95]e | 0.0260 | 1.21 [0.71-1.89]f | 0.4095 | |
| Obesity | 0.70 [0.44-1.11]e | 0.1320 | 1.03 [0.62-1.73]f | 0.9062 | |
HR=Hazard Ratio, CI=Confidence Interval, AMI=Acute Myocardial Infarction, BMI=Body Mass Index.
aParsimonious model adjusted for sex, age, stroke, smoking, re-infarction, any reperfusion treatment (coronary artery bypass surgery, percutaneous coronary intervention (PCI) or thrombolysis), beta-blockers (medication prior AMI), all four medications at discharge (antiplatelet agents, beta-blockers, Angiotensin-converting enzyme inhibitors (ACEIs)/Angiotensin receptor blockers (ARBs), statins), left ventricular ejection fraction (<30% versus ≥ 30%).
bParsimonious model adjusted for sex, age, hyperlipidemia, re-infarction, any reperfusion treatment, all four medications at discharge.
cEvidence-based medications (EBMs): Antiplatelet agents, beta-blockers, ACEIs/ARBs, statins.
dEither antiplatelet agents, beta-blockers, ACEIs/ARBs, statins or a combination of two or three of these medications.
eParsimonious model adjusted for sex, age, stroke, smoking, re-infarction, any reperfusion treatment, beta-blockers (medication prior AMI), left ventricular ejection fraction (<30% versus ≥ 30%).
fParsimonious model adjusted for sex, age, hyperlipidemia, re-infarction, any reperfusion treatment, statins (medication prior AMI).