. 2015 Jan 15;5(2):674–688.

Table 2.

Correlation between gene mutations and clinicopathological factors

	KRAS				BRAF			PIK3CA			PTEN

	WT	12 MT	13 MT	P value	WT	MT	P value	WT	MT	P value	WT	MT	P value
Total patients (n)	166	83	32		263	18		233	48		235	46
Age (year)				0.140			0.958			0.090			0.117
< 55	68	22	8		92	6		86	12		76	22
55-69	60	39	14		106	7		87	26		97	16
> 69	38	22	10		65	5		60	10		62	8
Sex				0.278			0.942			0.677			0.615
Male	109	46	19		163	11		143	31		144	30
Female	57	37	13		100	7		90	17		91	16
Primary tumor location				0.357			0.016			0.009			0.054
Right-sided	51	28	10		78	11		66	23		77	12
Left-sided	50	16	11		73	4		63	14		69	8
Rectum	65	39	11		112	3		104	11		89	26
Primary pT Stage				0.591			0.384			0.659			0.073
1-2	22	12	2		35	1		28	8		30	6
3	48	23	13		80	4		71	13		64	20
4	96	48	17		148	13		134	27		141	20
Primary pN Stage				0.053			0.091			0.460			0.731
0	61	39	9		101	8		88	21		93	16
1	52	24	17		91	2		76	17		78	15
2	53	20	6		71	8		69	10		64	15
Primary differentiation				0.498			0.252			0.759			0.288
Well to moderate	103	50	23		167	9		145	31		144	32
Poor	63	33	9		96	9		88	17		91	14
Primary histological type				0.376			0.084			0.078			0.326
Non-mucinous	140	64	26		218	12		195	35		190	40
Mucinous	26	19	6		45	6		38	13		45	6
Pre-primary resection CEA				0.076			0.194			0.562			0.954
< 5 ng/ml	81	24	14		115	4		99	20		101	18
5-200 ng/ml	59	38	12		98	11		92	17		90	19
> 200 ng/ml	11	13	3		26	1		23	4		22	5
Unknown	15	8	3		24	2		19	7		22	4
Distant metastases				< 0.001			0.006			0.314			0.829
No	68	24	4		92	4		83	13		81	15
Synchronous	49	36	7		80	12		72	20		78	14
Metachronous	49	23	21		91	2		78	15		76	17

Pearson χ² test was used in this analysis. WT: wild type; MT: mutant type; CEA: carcinoembryonic antigen. P value of < 0.01 was considered significant.