Table 4.
Multivariate analyses of common single nucleotide polymorphisms in KRAS mutations
| KRAS gene type | Metastases status | No vs. Syn. | No vs. meta. | Syn. vs. meta. | |||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
||||||
| No | Syn. | Meta. | OR | P value | OR | P value | OR | P value | |
| Total patients (n) | 96 | 92 | 93 | ||||||
| Wild type | 68 | 49 | 49 | 1 | - | 1 | - | 1 | - |
| c.35G > A, p.G12D | 14 | 18 | 9 | 2.006 | 0.235 | 1.147 | 0.798 | 0.548 | 0.331 |
| c.35G > T, p.G12V | 7 | 6 | 9 | 0.343 | 0.280 | 3.489 | 0.062 | 6.424 | 0.049 |
| c.34G > T, p.G12C | 2 | 8 | 1 | 11.667 | 0.026 | 2.675 | 0.483 | 0.057 | 0.043 |
| c.35G > C, p.G12A | 0 | 1 | 2 | NE | 1.000 | NE | 0.999 | 1.382 | 0.838 |
| c.34G > A, p.G12S | 0 | 2 | 2 | NE | 0.999 | NE | 0.999 | 1.243 | 0.869 |
| c.34G > C, p.G12R | 1 | 1 | 0 | 5.655 | 0.407 | NE | 1.000 | NE | 1.000 |
| c.38G > A, p.G13D | 4 | 7 | 21 | 1.822 | 0.510 | 13.686 | < 0.001 | 3.930 | 0.047 |
Multivariate analysis included all other clinical and pathological characteristics in Table 3, and logistic regression was used. Duplicate results were omitted in this table. OR: odds ratio; Syn.: synchronous; Meta.: metachronous; NE: not evaluable.