Table 5.

Univariate analyses of synchronous metastases within 6 months after primary tumor resection

	Metastases status				P1	P2	P3
	No	Syn.		Meta.
		Within 6 months	First diagnosis
Total patients (n)	96	6	86	93
Sex					0.684	0.722	0.738
Male	51	4	59	60
Female	45	2	27	33
Age					0.368	0.392	0.567
< 55	31	1	36	30
55-69	34	4	36	39
> 69	31	1	14	24
Primary tumor location					0.548	0.872	0.759
Right-sided	24	3	31	31
Left-sided	26	1	26	24
Rectum	46	2	29	38
Primary pT Stage					0.853	0.823	0.554
1/2	16	1	10	9
3	31	1	17	35
4	49	4	59	49
Primary pN Stage					0.473	1.000	1.000
0	45	2	28	34
1	35	2	24	32
2	16	2	34	27
Primary differentiation					1.000	0.700	1.000
G1-G2	64	4	49	59
G3-G4	32	2	37	34
Primary histological type					0.126	0.087	0.052
Non-mucinous	76	3	71	80
Mucinous	20	3	15	13
KRAS					0.730	0.699	1.000
Wild type	68	4	45	49
Codon 12 Mutant type	24	2	34	23
Codon 13 Mutant type	4	0	7	21
BRAF					0.039	0.174	0.018
Wild type	92	4	76	91
Mutant type	4	2	10	2
PIK3CA					0.829	0.755	0.972
Wild type	83	5	67	78
Mutant type	13	1	19	15
PTEN					0.946	0.919	0.921
Wild type	81	5	73	76
Mutant type	15	1	13	17
Pre-primary resection CEA					0.011	1.000	0.011
≤ 200 ng/ml	82	4	59	83
> 200 ng/ml	1	2	23	1
Unknown	13	0	4	9

P1: synchronous metastases within 6 months after primary tumor resection vs. no metastases. P2: synchronous metastases within 6 months after primary tumor resection vs. synchronous metastases at first diagnosis. P3: synchronous metastases within 6 months after primary tumor resection vs. metachronous metastases. Syn.: synchronous; Meta.: metachronous Within 6 months: metastases were diagnosed within 6 months after primary tumor resections. First diagnosis: metastases were detected before or during the primary tumor resection. Fisher’s exact test was used for samples with expected frequency < 5. CEA: carcinoembryonic antigen.