Table 1.

Relationship between TEM7 expression and clinicopathological features of gastric cancer patients in test and validation cohort

Variable	Test cohort (n = 289)				Validation cohort (n = 96)
	TEM7			P value	TEM7			P value
	(-)	(+)	(++)		(-)	(+)	(++)
Age at diagnosis (years)a
≤ 61	79	54	15	0.292	30	20	4	0.228
> 61	76	43	22		21	13	8
Gender
Male	107	62	23	0.592	34	19	10	0.267
Female	48	35	14		17	14	2
Lauren classification
Intestinal	51	26	10	0.515	17	6	5	0.196
Diffuse/mixed/not classified	104	71	27		34	27	7
Differentiation
Well	59	26	5	0.038*	27	8	2	0.018*
Moderate	45	31	13		14	16	4
Poor	51	40	19		10	9	6
Gross appearance
Borrmann I	10	5	4	0.093	3	2	0	0.199
Borrmann II	38	16	1		9	4	0
Borrmann III	101	72	30		38	22	11
Borrmann IV	6	4	2		1	5	1
Tumor size (cm)
≤ 5	103	67	25	0.911	39	20	7	0.219
> 5	52	30	12		12	13	5
Depth of tumor invasion (T)
T1	43	15	4	0.017*	18	3	0	0.014*
T2	23	17	6		9	5	0
T3	0	4	0		1	1	1
T4a	74	55	21		19	21	7
T4b	15	6	6		4	3	4
Lymphatic metastasis (N)
N0	80	42	9	0.022*	29	13	3	0.055
N1	26	17	10		8	7	1
N2	29	18	7		4	6	5
N3a	14	17	9		6	4	0
N3b	6	3	2		4	3	3
TNM stage
Ia	36	12	4	0.130	15	2	0	0.009**
Ib	21	11	1		7	4	0
IIa	6	10	4		4	2	1
IIb	31	20	6		10	9	2
IIIa	15	13	4		3	3	0
IIIb	19	11	6		1	6	5
IIIc	27	20	12		11	7	4
Vascular tumor thrombus
No	137	83	31	0.682	47	28	10	0.491
Yes	18	14	6		4	5	2
Perineural invasion
No	144	90	34	0.977	49	29	12	0.201
Yes	11	7	3		2	4	0
Signet ring cell carcinoma
No	134	91	34	0.156	43	25	12	0.150
Yes	21	6	3		8	8	0

^aMedian age of total 395 patients was 61 years;

^* P < 0.05;

^** P < 0.01.