Table 5.

The results of the univariate and multivariate analyses for clinicopathologic variables and the IHC expression associated with chemotherapy resistance in 92 patients of EOC

Variable	Univariate analysis		Multivariate analysis
	OR (95% CI)	P	OR (95% CI)	P
Age (> 60-year-old)	1.741 (0.616-4.916)	0.295
FIGO Stage (III-IV)	7.448 (2.325-23.857)	0.001	36.480 (4.029-330.290)	0.001
Differentiation (poor)	1.596 (0.852-2.990)	0.144
Pathological Subtype (others)	0.900 (0.372-2.175)	0.815
Lymph node metastasis (Yes)	2.646 (1.072-6.534)	0.035
Residual tumor size (> 1 cm)	5.467 (2.198-13.595)	< 0.001
Lewis y expression (high)	11.471 (4.033-32.627)	< 0.001	16.663 (2.273-122.137)	0.006
CD44 expression (high)	8.750 (3.296-23.232)	< 0.001	5.426 (1.072-27.460)	0.041
CD147 expression (high)	4.680 (1.881-11.643)	0.001
HE4 expression (high)	6.882 (2.674-17.712)	< 0.001	26.721 (3.423-208.576)	0.002
Integrin α5 expression (high)	6.882 (2.674-17.712)	< 0.001	12.060 (1.668-87.177)	0.014
Integrin β1 expression (high)	5.000 (1.976-12.651)	0.001	20.317 (2.220-185.962)	0.008
Integrin αv expression (high)	3.788 (1.552-9.242)	0.003
Integrin β3 expression (high)	2.870 (1.198-6.876)	0.018

Variables with P < 0.05 in the univariate analysis were included in the multivariate analysis. Abbreviation: HE4, Human epididymis protein 4.