Table 3.
Multivariate analysis of prognostic factors influencing the survival of breast cancer patients
| Characteristic | DFS | OS | ||||
|---|---|---|---|---|---|---|
|
|
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| Multivariate | Multivariate | |||||
|
|
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| HR | 95% CI | P | HR | 95% CI | P | |
| Number of RLNs (Model 1) | ||||||
| Age | 0.687 | 0.537-0.880 | 0.003* | 0.71 | 0.524-0.963 | 0.027* |
| Menopause status | ||||||
| pT stage | 1.250 | 1.102-1.418 | 0.001* | 1.296 | 1.112-1.511 | 0.001* |
| pN stage | 1.758 | 1.601-1.930 | < 0.001* | 1.766 | 1.603-1.966 | < 0.001* |
| Breast cancer subtypes | 1.288 | 1.197-1.385 | < 0.001* | 1.42 | 1.299-1.553 | < 0.001* |
| Number of RLNs | 0.982 | 0.967-0.997 | 0.022* | 0.987 | 0.968-1.006 | 0.185 |
| Number of NLNs (Model 2) | ||||||
| Age | 0.680 | 0.531-0.871 | 0.002* | 0.708 | 0.522-0.960 | 0.026* |
| Menopause status | ||||||
| pT stage | 1.241 | 1.095-1.407 | 0.001* | 1.29 | 1.107-1.503 | 0.001* |
| pN stage | 1.552 | 1.411-1.708 | < 0.001* | 1.632 | 1.451-1.836 | < 0.001* |
| Breast cancer subtypes | 1.278 | 1.188-1.375 | < 0.001* | 1.414 | 1.293-1.545 | <0.001* |
| Number of NLNs | 0.970 | 0.954-0.987 | 0.001* | 0.97 | 0.948-0.991 | 0.006* |
| LODDS (Model 3) | ||||||
| Age | — | — | — | 0.71 | 0.524-0.963 | 0.027* |
| Menopause status | — | — | — | — | — | — |
| pT stage | — | — | — | 1.293 | 1.112-1.511 | 0.001* |
| pN stage | — | — | — | 1.776 | 1.603-1.966 | < 0.001* |
| Breast cancer subtypes | — | — | — | 1.42 | 1.299-1.553 | < 0.001* |
| LODDS | — | — | — | 1.106 | 0.943-1.296 | 0.216 |
| LNR (Model 4) | ||||||
| Age | 0.691 | 0.539-0.885 | 0.003* | 0.724 | 0.534-0.983 | 0.037* |
| Menopause status | ||||||
| pT stage | 1.242 | 1.096-1.407 | 0.001* | 1.292 | 1.109-1.504 | 0.001* |
| pN stage | 1.300 | 1.086-1.557 | 0.004* | 1.346 | 1.082-1.674 | 0.008* |
| Breast cancer subtypes | 1.270 | 1.180-1.366 | < 0.001* | 1.401 | 1.281-1.532 | < 0.001* |
| LNR | 2.758 | 1.490-5.110 | 0.001* | 2.909 | 1.398-6.056 | 0.004* |
| Different lymph node staging methods (Model 5) | ||||||
| Age | 0.681 | 0.532-0.872 | 0.002* | 0.709 | 0.523-0.961 | 0.027* |
| Menopause status | ||||||
| pT stage | 1.244 | 1.098-1.411 | 0.001* | 1.293 | 1.110-1.507 | 0.001* |
| pN stage | 1.545 | 1.403-1.702 | < 0.001* | 1.625 | 1.443-1.830 | < 0.001* |
| Breast cancer subtype | 1.278 | 1.188-1.374 | < 0.001* | 1.413 | 1.293-1.545 | < 0.001* |
| Number of RLNs | 1.001 | 0.975-1.028 | 0.919 | 1.008 | 0.979-1.039 | 0.582 |
| Number of NLNs | 0.969 | 0.952-0.986 | <0.001* | 0.969 | 0.947-0.991 | 0.005* |
| LODDS | — | — | — | 1.038 | 0.882-1.222 | 0.651 |
| LNR | 1.588 | 0.630-4.002 | 0.327 | 1.571 | 0.513-4.813 | 0.429 |
DFS, disease-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; RLNs, removed lymph nodes; LODDS, log odds of positive lymph nodes; LNR, lymph node ratio; NLNs, negative lymph nodes.
*
P < .05, indicates a significant difference.