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HDAC3 is responsible for DTWD1 suppression. A. DTWD1 expression in gastric cancer cells before and after SB treatment was determined by real-time RT-PCR. Asterisks indicate statistical significance (p < 0.05, Student’s t test). B and C. The effect of HDACs depletion on DTWD1 expression in AGS and SGC7901 were determined by real-time RT-PCR. Asterisks indicate statistical significance (p < 0.05, Student’s t test). D. The binding of HDAC3 to the DTWD1 gene was determined by ChIP assay.
