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. 2015 Jan 15;5(2):663–673.

Figure 5.

Figure 5

HDAC3 regulates p53-mediated DTWD1 expression. A. The effect of TSA on p53 expression in SGC7901 was determined by Western blotting. B. The effect of TSA on the binding of p53 to DTWD1 gene was determined by ChIP assay. The asterisk indicates statistical significance (p < 0.05). C. The effect of TSA and p53 depletion on DTWD1 expression was determined by real-time RT-PCR in SGC7901. The asterisk indicates statistical significance (p < 0.05, Student’s t test). D. The effect of HDAC3 depletion on p53 and HDAC3 expression in SGC7901 cells was determined by Western blotting. E. The effect of HDAC3 depletion on the binding of p53 to DTWD1 gene was determined by ChIP assay. The asterisk indicates statistical significance (p < 0.05). F. The effect of HDAC3 depletion and p53 depletion on DTWD1 expression in SGC7901 cells was determined by real-time RT-PCR. The asterisk indicates statistical significance (p < 0.05, Student’s t test).