Figure 3.

CircRNAs involvement in cancer: from bench to clinic. At the cell level, the specific circRNA and its role in function are discovered and identified. In the in vivo experiment, the transgenic mouse is created and then the specific circRNA is delivered to this animal model to analyze the changes in phenotype. Prior to the clinic trial, the functional target circRNA is screened from cancer patient. The targeted therapy can be used in humans by delivering the therapeutic circRNA to various cancer patients.