Table 4.

Univariate and multivariate analysis of factors associated with HCC recurrence in HBeAg negative patients with low viral load

Factor	n	Recurrence rate (%)		Univariate analysis (p value)	Multivariate Analyses (p value)	Hazard ratio	95% CI
		1-year	3-year
Gender				0.331	NA	NA	NA
Male	253	24.5	43.5
Female	50	16.0	40.0
Age				0.670	NA	NA	NA
< 50	118	22.9	39.8
50-59	105	24.8	45.7
≥ 60	80	21.3	43.8
Cirrhosis				0.098	0.075	1.550	0.957-2.509
Yes	170	24.7	47.6
No	133	21.1	36.8
Diabetes				0.001	0.188	1.649	0.783-3.472
Yes	13	15.4	84.6
No	290	23.4	41.0
Serum HBsAg level (S/CO)				0.014	0.107	1.549	0.910-2.638
< 2000	84	19.0	31.0
≥ 2000	219	24.7	47.5
Serum HBV DNA level (IU/ml)				0.550	NA	NA	NA
< 1000	273	23.1	42.5
1000-1999	30	23.3	46.7
ALT (U/L)				0.186	NA	NA	NA
≤ 41	228	23.7	40.4
> 41	75	21.3	50.7
AST (U/L)				0.045	0.483	0.818	0.465-1.436
≤ 37	226	20.4	39.8
> 37	77	31.2	51.9
TBIL (μmol/L)				0.918	NA	NA	NA
≤ 18.8	252	22.2	43.3
> 18.8	51	27.5	41.2
γ-GT (U/L)				< 0.001	0.001	2.346	1.430-3.849
≤ 61	181	17.1	30.4
> 61	122	32.0	61.5
ALP (U/L)				0.103	NA	NA	NA
≤ 129	269	21.9	41.6
> 129	34	32.4	52.9
AFP (μg/L)				0.140	NA	NA	NA
≤ 20	135	14.8	40.0
> 20	168	29.8	45.2
ALB (g/L)				0.285	NA	NA	NA
< 34	2	0.0	0.0
≥ 34	301	23.3	43.2
Prealbumin (mg/L)				0.006	0.383	1.265	0.746-2.147
< 170	59	35.6	57.6
≥ 170	244	20.1	39.3
PT (s)				0.392	NA	NA	NA
≤ 13	270	21.9	42.2
> 13	33	33.3	48.5
WBC (*109/L)				0.825	NA	NA	NA
< 4	51	25.5	45.1
≥ 4	252	22.6	42.5
PLT (*109/L)				0.805	NA	NA	NA
< 100	44	25.0	45.5
≥ 100	259	22.8	42.5
Tumor number				< 0.001	0.941	1.020	0.606-1.716
single	250	19.2	38.4
multiple	53	41.5	64.2
Tumor size (cm)				< 0.001	0.230	1.178	0.901-1.541
≤ 3	95	8.4	30.5
3~5	99	20.2	39.4
5~10	82	35.4	56.1
> 10	27	48.1	59.3
Capsule formation				0.002	0.007	0.488	0.291-0.819
Yes	244	20.9	39.8
No	59	32.2	55.9
Edmonson grading				0.071	0.649	0.897	0.563-1.431
I	6	16.7	33.3
II	70	10.0	32.9
III	216	25.9	45.4
IV	11	54.5	63.6
Portal vein invasion				< 0.001	0.812	1.080	0.571-2.043
Yes	29	55.2	79.3
No	274	19.7	39.1
Microvascular invasion				< 0.001	0.001	2.215	1.367-3.589
Yes	104	42.3	58.7
No	199	13.1	34.7
Cutting margin (cm) (n = 224)a				0.004	0.067	0.470	0.210-1.055
< 1	187	25.7	45.5
≥ 1	37	10.8	18.9

HCC, hepatocellular carcinoma; HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; WBC, white blood cell; PLT, platelet; AFP, alpha-fetoprotein; TBIL, total bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; PT, prothrombin time; γ-GT, γ-glutamyl transpeptidase; ALP, alkaline phosphatase.

^aNumber of available data.