Table 1.

A complete list of search terms and strategies

Set	Concept	Search statement
1	Oral	Oral cavity
2	Oral biopsy	Surgical biopsy, Toluidine blue staining, Oral brush biopsy, Optical Biopsy
3	Optical Biopsy	Fluorescence spectroscopy, Raman spectroscopy, Elastic scattering spectroscopy, Differential path-length spectroscopy, Optical Tomography
4	Fluorescence spectroscopy	Auto-fluorescence spectroscopy, Enhanced dye fluorescence, Ratio imaging
5	Oral diseases	Tumors, carcinoma
6	Combined set	2, 5
7	Combined set	3, 5
8	Combined set	3, 4, 5
9	Saliva	Saliva-based oral cancer diagnosis,
10	Oral Saliva changes in cancer patients	Genomic substance, Transcriptomic mRNA, Proteomic substances
11	Combined set	9, 10
12	Combined set	6, 7, 8, 11
13	Limit by publication type	5,6, 8, 11, 12: Not letter or editorial or news or comments or case report or notes or conference paper
14	Diagnostics filter	13 and (predictive value of tests or sensitivity and specificity or accuracy or diagnostic accuracy or precision or likelihood) or (false or true) or (positive or negative)
15	Clinical trials filter	14 and (Randomized controlled trials or random allocation or double-blind method or single-blind method or cross-over studies or crossover procedure or double blind procedure or single blind procedure or crossover design or double-blind studies or single-blind studies or triple-blind studies or random assignment or exp controlled study/or exp clinical trial/or exp comparative study or intermethod comparison or parallel design or control group or prospective study or case control study or major clinical study) or Case control studies/or Cohort/or Longitudinal studies/or Evaluation studies/or Prospective studies
16	Combined set	14, 15
17	Patient satisfaction	13 and (patient satisfaction or pain measurement or pain assessment or visual analog scale or quality of life).