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. 2015 Mar;10(3):385–390. doi: 10.4103/1673-5374.153685

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Estradiol and tamoxifen (TAM) improve the behavioral performance of injured rats in the beam crossing test.

Ovariectomized rats were treated with estradiol (3 mg) or tamoxifen (15 mg), either by silastic tubing or commercial pellets, respectively, 1 week prior to spinal cord injury. The injured rats were tested weekly and the number of rats that crossed the narrow beam was analyzed with analysis of varivance followed by Bonferroni post hoc test. Results demonstrated a significance difference between control (n = 13) and treated (estradiol: n = 12; TAM: n = 10) animals (*P < 0.0016).