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. 2015 Mar;10(3):385–390. doi: 10.4103/1673-5374.153685

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Neuroprotective and neurodegenerative effects of TAM and PP2 in spinal cord injury.

TAM (A) and PP2 (B) are drugs that in a moderate spinal cord injury act as neuroprotective and neuroregenerative agents that promote functional locomotor recovery and increase spared white matter tissue. Additionally, TAM plays an important role as superoxide scavenger. ↑ Increase; ↓ decrease; TAM: tamoxifen; PP2: Src kinase inhibitor; ROS: reactive oxygen species; NF: neurofilament; NeuN: neuronal transcription factor; 5HT: 5-hydroxytryptamine; BBB: blood brain barrier; GAP-43: growth associated protein 43; GFAP: glial fibrillary acidic protein.