Figure 5.
Over-expression of SMAD3 reduced the levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) mRNA in ischemic brain of rats 24 hours after reperfusion.
In the control, SMAD3 and vector groups, rats were injected via the tail vein with 100 μL PBS, AAV9-SMAD3 (3 × 1013 vg/mL per kg body weight), and AAV9-SMAD3 control AAV9-GFP (3 × 1013 vg/mL per kg body weight), respectively. *P < 0.05, **P < 0.01, vs. controls (one-way analysis of variance followed by Student-Newman-Keul test). Data are presented as the mean ± SD from at least three independent experiments.