Table 4.
Comparison of multiplex assay analytes in PTSD patients (n = 47) between two assessments.
| Analyte | Median (Q1–Q3) |
Detectable (%) |
Statistical valuea | d-valueb | p-valuec | ||
|---|---|---|---|---|---|---|---|
| Time 1 | Time 2 | Time 1 | Time 2 | ||||
| sCD40L | 4.76 (3.75–5.68) | 4.26 (3.71–4.78) | 47 (100) | 47 (100) | −3.99 | 0.008 | <0.001* |
| sPECAM-1 | 204.84 (166.08–286.69) | 162.17 (120.78–213.94) | 47 (100) | 47 (100) | −5.82 | 0.002 | <0.001* |
| sICAM-1 | 589.47 (470.83–787.31) | 635.40 (468.53–1008.13) | 47 (100) | 47 (100) | 1.32 | 0.021 | 0.194 |
| Leptin | 15.73 (8.41–26.67) | 13.50 (0.66–23.18) | 47 (100) | 47 (100) | 1.73 | 0.015 | 0.091 |
| MIP-1α | 30.28 (0.00–111.81) | 32.33 (14.76–67.67) | 35 (75) | 43 (92) | 1.20 | 0.023 | 0.236 |
| IL-8 | 33.95 (0.00–135.12) | 191.87 (55.22–405.51) | 31 (66) | 40 (85) | 4.65 | 0.004 | <0.001* |
| IL-1β | 0.00 (0.00–34.47) | 18.21 (0.00–31.51) | 21 (44) | 32 (68) | 2.13 | 0.013 | 0.012* |
| IL-2 | 0.00 (0.00–0.00) | 0.00 (0.00–100.53) | 9 (19) | 21 (45) | Exact | 0.010 | 0.004* |
| TNF-α | 0.00 (0.00–0.00) | 0.00 (0.00–10.63) | 10 (21) | 12 (26) | Exact | 0.044 | 0.791 |
| IFN-γ | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 10 (21) | 7 (15) | Exact | 0.031 | 0.375 |
| NGF | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 5 (11) | 1 (2) | Exact | 0.017 | 0.125 |
| IL-4 | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 4 (9) | 4 (9) | Exact | 0.050 | 0.999 |
| IL-6 | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 1 (2) | 9 (19) | Exact | 0.040 | 0.008* |
See Table 3 for abbreviations.
at-value: dependent sample t-tests calculated for log-transformed variables (except IL-1β, Z-value: Wilcoxon signed-rank tests), “Exact”: McNemar’s exact test.
bFalse discovery rate threshold value (d) calculated with significance level (α) set to 0.05 for 26 comparisons.
cThe difference is considered significant at α = 0.05 if p-value is less than the corresponding d value (labeled with *).