Table 1.

Suggested pathophysiological mechanisms for the effect of NIV during exercise

Setting	Mechanism
IPAP	WOB reduction
	Respiratory Muscle unloading
	Limb blood flow switch
	Anti inflammatory action
	Reduction in Vagal Tone
PEEP	Reduction in iPEEP

Abbreviations: IPAP, Inspiratory Positive Airway Pressure; PEEP, Positive End Expiratory Pressure; iPEEP, Intrinsic Positive End Expiratory Pressure; WOB: Work of Breathing.