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Relationships between plasma and cerebrospinal fluid (CSF) unbound drug concentrations for atazanavir (ATV) and darunavir (DRV). (a) ATV (blue diamonds), Spearman rank correlation coefficient r = 0.77, P < 0.01, and (b) DRV (red diamonds), Spearman rank correlation coefficient r = 0.72, P < 0.01.
