. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: J Clin Pharmacol. 2014 Apr 8;54(9):1063–1071. doi: 10.1002/jcph.298

Table 3.

HIV-1 RNA and Neopterin Levels in CSF and Plasma

	Atazanavir (n = 15)	Darunavir (n = 15)	P-Value Comparing Arms
Detectable CSF HIV-1 RNA^a, n (%)	2 (13.3)	4 (26.7)	0.7
Median copies/mL (IQR)	220 (120–320)	50 (45–55)
Detectable plasma HIV-1 RNA, n (%)	10 (66.7)	4 (26.7)	0.03
Median copies/mL (IQR)	225 (140–310)	200 (95–3520)
CSF neopterin in ng/mL, mean (SD)	1.8 (0.7)	1.7 (0.4)	0.9
Plasma neopterin in ng/mL, mean (SD)	2.0 (0.9)	1.7 (0.4)	0.3

Continuous variables compared between arms using two-sided two-sample t-test.

Categorical variables compared between arms using Chi-square test or Fisher's exact test.

CSF, cerebrospinal fluid; SD, standard deviation.

Detectable HIV-1 RNA defined as ≥40 copies/mL