Table 2.

Associations between eicosanoid/urine creatinine and eGFR or Urine Protein

	eGFR		Proteinuria^†

	Unadj	Fully Adj*	Unadj	Fully Adj*
20-HETE	19.44 p=0.001 (8.26, 30.62)	17.47 p=0.001 (7.37, 27.57)	1.23 p=0.307 (0.83, 1.83)	1.39 p=0.175 (0.86, 2.25)
20-HETE	R2 0.05	R2 0.31	-	-
19-HETE	12.56 p=0.028 (1.37, 23.75)	60.68 p=0.005 (18.48, 102.88)	0.98 p=0.960 (0.43, 2.21)	22.12 p=0.003 (2.80, 175.05)
19-HETE	R2 0.02	R2 0.31	-	-
15-HETE	23.12 p=0.060 (−0.99, 47.22)	7.97 p=0.710 (−34.34, 50.28)	0.39 p=0.009 (0.19, 0.79)	0.09 p=0.016 (0.01, 0.63)
15-HETE	R2 0.02	R2 0.24	-	-
12-HETE	3.40 p=0.141 (−1.14, 7.94)	−5.07 p=0.195 (−12.78, 2.63)	0.95 p=0.572 (0.78, 1.14)	1.06 p=0.720 (0.77, 1.45)
12-HETE	R2 0.01	R2 0.27	-	-
8-HETE	119.01 p<0.001 (57.03, 180.99)	378.89 p=0.001 (160.01, 597.77)	0.06 p=0.001 (0.01, 0.33)	0.09 p=0.623 (0.00, 1293.61)
8-HETE	R2 0.08	R2 0.31	-	-
14,15-diHETE	9.00 p=0.002 (3.24, 14.77)	9.83 p=0.062 (−0.50, 20.17)	0.81 p=0.029 (0.67, 0.98)	0.85 p=0.617 (0.45, 1.62)
14,15-diHETE	R2 0.04	R2 0.28	-	-
11,12-diHETE	49.28 p<0.001 (22.27, 76.28)	183.83 p<0.001 (87.50, 280.16)	0.34 p=0.003 (0.17, 0.70)	0.03 p=0.152 (0.00, 3.62)
11,12-diHETE	R2 0.07	R2 0.32	-	-
8,9-diHETE	6.01 p<0.001 (3.96, 8.06)	8.33 p<0.001 (5.56, 11.10)	0.90 p<0.001 (0.85, 0.95)	0.94 p=0.378 (0.81, 1.08)
8,9-diHETE	R2 0.13	R2 0.40	-	-
5,6-diHETE	39.09 p<0.001 (22.08, 56.10)	112.04 p<0.001 (74.27, 149.81)	0.46 p<0.001 (0.31, 0.70)	0.30 p=0.163 (0.05, 1.64)
5,6-diHETE	R2 0.09	R2 0.39	-	-

For eGFR outcomes, beta coefficients (slope) with p-values, 95% confidence intervals, and r values are shown. For proteinuria outcomes, incidence rate ratios (IRR) are reported with p-values and 95% confidence intervals. Unadjusted and fully adjusted models are shown, with fully adjusted models having age, gender, BMI, systolic blood pressure, diastolic blood pressure, diabetes, lupus, and medications from table 3 used as confounders.