Table 3b.
Medication | Eicosanoid
|
|||
---|---|---|---|---|
14,15-diHETE | 11,12-diHETE | 8,9-diHETE | 5,6-diHETE | |
Beta-blockers | 0.89 p=0.452 (0.66, 1.20) | 0.86 p=0.323 (0.64, 1.16) | 0.81 p=0.153 (0.60, 1.08) | 0.75 p=0.044 (0.57, 0.99) |
ACEI | 0.80 p=0.127 (0.61, 1.06) | 0.90 p=0.483 (0.68, 1.20) | 1.03 p=0.842 (0.77, 1.37) | 1.14 p=0.372 (0.86, 1.51) |
ARB | 1.10 p=0.618 (0.75, 1.62) | 1.08 p=0.690 (0.74, 1.56) | 1.19 p=0.373 (0.81, 1.73) | 1.02 p=0.909 (0.70, 1.49) |
Eplerenone/spironolactone | 0.90 p=0.674 (0.57, 1.44) | 0.99 p=0.975 (0.65, 1.52) | 0.93 p=0.756 (0.58, 1.49) | 0.85 p=0.489 (0.53, 1.36) |
Ca channel blocker | 0.75 p=0.072 (0.56, 1.03) | 0.81 p=0.153 (0.60, 1.08) | 0.79 p=0.123 (0.59, 1.06) | 0.76 p=0.059 (0.57, 1.01) |
Diuretic | 0.77 p=0.143 (0.55, 1.09) | 0.60 p=0.002 (0.43, 0.83) | 0.74 p=0.082 (0.52, 1.04) | 0.67 p=0.021 (0.48, 0.94) |
Statin | 1.16 p=0.361 (0.85, 1.59) | 1.17 p=0.310 (0.86, 1.60) | 0.89 p=0.482 (0.66, 1.22) | 0.99 p=0.959 (0.73, 1.34) |
Other immunosuppressive | 1.32 p=0.522 (0.56, 3.08) | 1.36 p=0.506 (0.55, 3.38) | 1.31 p=0.463 (0.64, 2.67) | 1.20 p=0.610 (0.60, 2.38) |
Steroids | 1.20 p=0.480 (0.73, 1.96) | 1.18 p=0.475 (0.74, 1.88) | 1.59 p=0.051 (1.00, 2.53) | 1.51 p=0.067 (0.97, 2.34) |
Tables 3a and 3B. Associations between medications and eicosanoids. Shown are incidence rate ratios (IRR), p-values, and 95% confidence intervals. All models are adjusted for age, gender, BMI, systolic blood pressure, diastolic blood pressure, diabetes, and lupus.