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. Author manuscript; available in PMC: 2015 Apr 14.
Published in final edited form as: Hepatology. 2010 Jan;51(1):54–62. doi: 10.1002/hep.23275

Fig. 2.

Fig. 2

CD8+ T cells specific for the genotype 1 HLA-B27 NS5B2841-2849 epitope do not cross-recognize the corresponding genotype 3a peptide. PBMC from an HLA-B27+ patient chronically infected with HCV genotype 1 were stimulated for 2 weeks with the genotype 1 HLA-B27 NS5B2841-2849 epitope peptide (ARMILMTHF). The resulting CTL line was restimulated for 5 hours prior to intracellular INF-γ staining either with the genotype 1 peptide at different concentrations as indicated (upper panel) or with the corresponding genotype 3a peptide (V RM VM MTHF) (lower panel). Percent values indicate the subset of IFN-γ+ CD8+ T cells after subtracting the background in the absence of peptide.