Table 2.

Univariate and multivariate cox regression analyses for recurrence-free survival and overall survival

Variable	Recurrence-free survival			Overall survival
		Multivariate			Multivariate
	Univariate P	HR (95% CI)	P	Univariate P	HR (95% CI)	P
Age, yr	0.133			0.122
Gender (male vs female*)	0.641			0.489
Tumor size, cm	< 0.001	1.103 (1.004-1.212)	0.042	< 0.001	1.118 (1.005-1.243)	0.040
Pathologic T stage
T3+T4 vs T1+T2*	< 0.001	2.642 (1.564-4.463)	< 0.001	< 0.001	2.767 (1.545-4.957)	0.001
Fuhrman grade (3+4 vs 1+2*)	< 0.001	2.459 (1.472-4.108)	0.001	0.004	2.138 (1.204-3.796)	0.009
Necrosis (present vs absent*)	0.018	1.145 (0.632-2.007)	0.655	0.012	1.312 (0.684-2.517)	0.413
ECOG PS (≥ 1 vs. 0*)	0.001	1.587 (0.875-2.878)	0.129	0.002	1.593 (0.818-3.100)	0.171
Combination of IL-4 and IL-13a	0.001		0.029	0.006		0.051
Either high vs both low*	0.053	1.931 (0.929-4.015)	0.078	0.417	1.435 (0.610-3.377)	0.408
Both high vs both low*	< 0.001	2.277 (1.233-4.204)	0.009	0.002	2.268 (1.163-4.423)	0.016

HR = hazard ratio; CI = confidence interval; ECOG-PS = Eastern Cooperative Oncology Group performance status.

^*Reference group.

^aOverall P value is provided, and HR, 95% CI, and P values are provided for each level.