. 2015 Feb 1;8(2):1911–1919.

Table 3.

Overall and subgroup analysis of XRCC3 gene rs861539 (Thr241Met) polymorphism and gastric cancer

Subgroup	Study number	Thr vs Met				Thr/Thr vs Met/Met				Dominant				Recessive

		OR (95% CI)	P	I² (%)	pheterogeneity	OR (95% CI)	P	I² (%)	pheterogeneity	OR (95% CI)	P	I² (%)	pheterogeneity	OR (95% CI)	P	I² (%)	pheterogeneity
Total	10	0.89	0.504	92.2	0.08	0.86	0.624	86.9	< 0.001	0.89	0.600	77.9	< 0.001	0.88	0.538	90.6	< 0.001
Total	10	(0.65, 1.24)	0.504	92.2	0.08	(0.46, 1.58)	0.624	86.9	< 0.001	(0.57, 1.39)	0.600	77.9	< 0.001	(0.60, 1.31)	0.538	90.6	< 0.001
Ethnicity
Asians	4	0.62	0.033	86.5	< 0.001	0.32	< 0.001	35.1	0.202	0.39	< 0.001	0	0.532	0.58	0.054	88.6	< 0.001
Asians	4	(0.40, 0.96)	0.033	86.5	< 0.001	(0.18, 0.58)	< 0.001	35.1	0.202	(0.29, 0.51)	< 0.001	0	0.532	(0.34, 1.01)	0.054	88.6	< 0.001
Caucasians	5	1.05	0.432	0	0.523	1.16	0.281	0	0.467	1.15	0.280	0	0.478	1.03	0.735	1.0	0.401
Caucasians	5	(0.93, 1.19)	0.432	0	0.523	(0.88, 1.53)	0.281	0	0.467	(0.89, 1.48)	0.280	0	0.478	(0.86,1.23)	0.735	1.0	0.401
Others	1	1.22	0.245	/	/	1.25	0.503	/	/	1.08	0.813	/	/	1.37	0.168	/	/
Others	1	(0.87, 1.71)	0.245	/	/	(0.65, 2.43)	0.503	/	/	(0.58, 2.02)	0.813	/	/	(0.88, 2.14)	0.168	/	/
Study design
HCC	5	0.77	0.307	93.0	< 0.001	0.62	0.309	85.7	< 0.001	0.64	0.132	67.5	0.015	0.76	0.404	93.0	< 0.001
HCC	5	(0.46, 1.28)	0.307	93.0	< 0.001	(0.25, 1.56)	0.309	85.7	< 0.001	(0.36, 1.14)	0.132	67.5	0.015	(0.40, 1.44)	0.404	93.0	< 0.001
PCC	5	1.04	0.578	0	0.542	1.15	0.324	1.1	0.400	1.16	0.256	0	0.457	1.00	0.981	0	0.631
PCC	5	(0.91, 1.18)	0.578	0	0.542	(0.87, 1.54)	0.324	1.1	0.400	(0.90, 1.51)	0.256	0	0.457	(0.84, 1.19)	0.981	0	0.631

Abbreviations: HCC = Hospital-based case-control study; PCC = Population-based case-control study; OR = odds ratio; CI = confidence interval.