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. 2015 Feb 1;8(2):1565–1574.

Figure 3.

Figure 3

miR-29c mimics transfection inhibits BACE1 expression and APPβ accumulation in SH-SY5Y cells. A: Manipulated high level of miR-29c level in SH-SY5Y cells, by miR-29c mimics transfection, scrambled oligonucleotide as control. miR-29c level was examined by RT-qPCR, with U6 as internal control. B: miR-29c mimics transfection reduced the BACE1 expression in mRNA level, as was quantified by RT-qPCR; C: Western blot assay indicated a reduced BACE1 expression in protein level; D: Western blot analysis of accumulated APPβ in SH-SY5Y cells which were transfected with miR-29c mimics or scrambled oligonucleotide. All results were averaged from triplicate independent experiments. *P < 0.05, ***P < 0.001.