Table 1.
Clinicopathological features according to nuclear maspin expression status in MSI-H CRCs (n = 216)
| Clinicopathological factors | Total cases | Nuclear maspin-positive | Nuclear maspin-negative | P value | |
|---|---|---|---|---|---|
| Agea | < 58 years | 102 | 52 (47%) | 50 (48%) | 0.91 |
| ≥ 58 years | 114 | 59 (53%) | 55 (52%) | ||
| Gender | Male | 115 | 55 (50%) | 60 (57%) | 0.264 |
| Female | 101 | 56 (50%) | 45 (43%) | ||
| Tumor location | Proximal | 139 | 82 (74%) | 57 (54%) | 0.003 |
| Distal | 77 | 29 (26%) | 48 (46%) | ||
| Tumor multiplicity | Solitary | 194 | 97 (87%) | 97 (92%) | 0.225 |
| Multiple | 22 | 14 (13%) | 8 (8%) | ||
| Gross tumor type | Polypoid | 31 | 17 (15%) | 14 (13%) | 0.678 |
| Ulcerative | 185 | 94 (85%) | 91 (87%) | ||
| Tumor border | Expanding | 35 | 17 (15%) | 18 (17%) | 0.716 |
| Infiltrative | 181 | 94 (85%) | 87 (83%) | ||
| AJCC/UICC TNM stage | Stage I/II | 139 | 60 (54%) | 79 (75%) | 0.001 |
| Stage III/IV | 77 | 51 (46%) | 26 (25%) | ||
| Lymph node metastasis | Absent | 143 | 63 (57%) | 80 (76%) | 0.003 |
| Present | 73 | 48 (43%) | 25 (24%) | ||
| Distant metastasis | Absent | 198 | 96 (86%) | 102 (97%) | 0.005 |
| Present | 18 | 15 (14%) | 3 (3%) | ||
| Lymphovascular invasion | Absent | 159 | 71 (64%) | 88 (84%) | 0.001 |
| Present | 57 | 40 (36%) | 17 (16%) | ||
| Perineural invasion | Absent | 199 | 97 (87%) | 102 (97%) | 0.008 |
| Present | 17 | 14 (13%) | 3 (3%) | ||
| Tumor budding | Negative | 171 | 77 (69%) | 94 (90%) | < 0.001 |
| Positive | 45 | 34 (31%) | 11 (10%) | ||
| Tumor differentiation | WD/MD | 171 | 87 (78%) | 84 (80%) | 0.769 |
| PD | 45 | 24 (22%) | 21 (20%) | ||
| Mucinous histology | Absent | 93 | 41 (37%) | 52 (50%) | 0.062 |
| Present | 123 | 70 (63%) | 53 (50%) | ||
| Signet ring cell histology | Absent | 196 | 97 (87%) | 99 (94%) | 0.08 |
| Present | 20 | 14 (13%) | 6 (6%) | ||
| Medullary histology | Absent | 209 | 106 (95%) | 103 (98%) | 0.447 |
| Present | 7 | 5 (5%) | 2 (2%) | ||
| Serrated histology | Absent | 193 | 98 (88%) | 95 (90%) | 0.602 |
| Present | 23 | 13 (12%) | 10 (10%) | ||
| Cribriform comedo histology | Absent | 202 | 104 (94%) | 98 (93%) | 0.914 |
| Present | 14 | 7 (6%) | 7 (7%) | ||
| Peritumoral lymphoid reaction | Absent | 16 | 12 (11%) | 4 (4%) | 0.045 |
| Present | 194 | 95 (89%) | 99 (96%) |
Abbreviations: AJCC/UICC, American Joint Committee on Cancer/International Union against Cancer; TNM, tumor-node-metastasis; WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated;
a
Age subgroups were dichotomously classified using a cutoff value of the average age (58 years) of study patients.