Table 2.
Molecular features according to nuclear maspin expression status in MSI-H CRCs (n = 216)
| Molecular factors | Total cases | Nuclear maspin-positive | Nuclear maspin-negative | P value | |
|---|---|---|---|---|---|
| MLH1 expression | Loss | 138 | 74 (67%) | 64 (61%) | 0.382 |
| Retained | 78 | 37 (33%) | 41 (39%) | ||
| MSH2 expression | Loss | 66 | 33 (30%) | 33 (31%) | 0.786 |
| Retained | 150 | 78 (70%) | 72 (69%) | ||
| MSH6 expression | Loss | 73 | 39 (35%) | 34 (32%) | 0.669 |
| Retained | 143 | 72 (65%) | 71 (68%) | ||
| PMS2 expression | Loss | 145 | 77 (69%) | 68 (65%) | 0.471 |
| Retained | 71 | 34 (31%) | 37 (35%) | ||
| CIMP status | CIMP-H | 56 | 40 (36%) | 16 (15%) | < 0.001 |
| CIMP-L/0 | 160 | 71 (64%) | 89 (85%) | ||
| MLH1 methylation | Methylated | 64 | 43 (39%) | 21 (20%) | 0.003 |
| Unmethylated | 152 | 68 (61%) | 84 (80%) | ||
| NEUROG1 methylation | Methylated | 62 | 42 (38%) | 20 (19%) | 0.002 |
| Unmethylated | 154 | 69 (62%) | 85 (81%) | ||
| CACNA1G methylation | Methylated | 59 | 39 (35%) | 20 (19%) | 0.008 |
| Unmethylated | 157 | 72 (65%) | 85 (81%) | ||
| CRABP1 methylation | Methylated | 112 | 65 (59%) | 47 (45%) | 0.043 |
| Unmethylated | 104 | 46 (41%) | 58 (55%) | ||
| p16 methylation | Methylated | 88 | 56 (50%) | 32 (30%) | 0.003 |
| Unmethylated | 128 | 55 (50%) | 73 (70%) | ||
| IGF2 methylation | Methylated | 58 | 40 (36%) | 18 (17%) | 0.002 |
| Unmethylated | 158 | 71 (64%) | 87 (83%) | ||
| RUNX3 methylation | Methylated | 62 | 43 (39%) | 19 (18%) | 0.001 |
| Unmethylated | 154 | 68 (61%) | 86 (82%) | ||
| SOCS1 methylation | Methylated | 84 | 44 (40%) | 40 (38%) | 0.816 |
| Unmethylated | 132 | 67 (60%) | 65 (62%) | ||
| KRAS mutation | Wild type | 168 | 89 (82%) | 79 (79%) | 0.63 |
| Mutant | 41 | 20 (18%) | 21 (21%) | ||
| BRAF mutation | Wild type | 189 | 96 (87%) | 93 (89%) | 0.77 |
| Mutant | 26 | 14 (13%) | 12 (11%) |
Abbreviations: CIMP, CpG island methylator phenotype; CIMP-H, CIMP-high; CIMP-L/0, CIMP-low or CIMP-negative.